KCTD17 Antibodies

AND KCTD17 ELISA kits, KCTD17 Proteins

Many biological assays use antibodies to detect KCTD17, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCTD17 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCTD17 antibodies...

We validate the specificity of these antibodies to KCTD17 by testing them on tissues known to express KCTD17 positively and negatively. Browse below to find the KCTD17 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KCTD17 Infographic by Boster Bio

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KCTD17 (NM_024681) Human Over-expression Lysate

Human

$628
Cat # LS079734
100 µg

KCTD17 Overview

Facts about BTB/POZ domain-containing protein KCTD17.

KCTD17 3D structure. Source: alphafold

BTB/POZ domain-containing protein KCTD17 (KCTD17)

Is a positive regulator of ciliogenesis, playing a crucial role in the first steps of axoneme expansion. It functions as a substrate-adapter for CUL3-RING ubiquitin ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down-regulation (PubMed:25270598).

May be involved in endoplasmic reticulum calcium ion homeostasis (PubMed:25983243). .

Gene Information

Human
Gene Name:	KCTD17
Uniprot:	Q8N5Z5
Entrez:	79734

Family

Belongs to:

No superfamily

Alternative Names

BTB/POZ domain-containing protein KCTD17; FLJ12242; FLJ98761; potassium channel tetramerisation domain containing 17

Molecular Weight

Mass (kDA):
35.67 kDA

Genomic Context


Human

Location:	22q12.3
Sequence:	22; NC_000022.11 (37051725..37063390)

Tissue Specificity

Highly expressed in brain. Highest expression is observed in the putamen and the thalamus.

Subcellular Localizations

Cytoplasm.

Diseases

Dystonia 26, myoclonic (DYT26)

Interacting Proteins

DMC1
STK16
SUV39H2
TINF2

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCTD17

References

PMID: 25270598 by Kasahara K., et al. Ubiquitin-proteasome system controls ciliogenesis at the initial step of axoneme extension.

PMID: 25983243 by Mencacci N.E., et al. A missense mutation in KCTD17 causes autosomal dominant myoclonus- dystonia.