KCNQ4 Antibodies

AND KCNQ4 ELISA kits, KCNQ4 Proteins

Many biological assays use antibodies to detect KCNQ4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNQ4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNQ4 antibodies...

We validate the specificity of these antibodies to KCNQ4 by testing them on tissues known to express KCNQ4 positively and negatively. Browse below to find the KCNQ4 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KCNQ4 Infographic by Boster Bio

All KCNQ4 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-KCNQ4/Kv7.4 Antibody

Human

$360
Cat # A03659
100 µl

Anti-KCNQ4/Kv7.4 Antibody

5 Q&As

Human, Mouse

$399
Cat # A03659-1
100μl

Anti-Kv7.4 KCNQ4 Antibody

Human, Mouse, Rat

$405
Cat # A03659-2
100ul

KCNQ4 (NM_172163) Human Recombinant Protein

$813
Cat # PROTP56696
20 µg

KCNQ4 (NM_004700) Human Over-expression Lysate

Human

$960
Cat # LS009132
100 µg

KCNQ4 Overview

Facts about Potassium voltage-gated channel subfamily KQT member 4.

KCNQ4 3D structure. Source: alphafold

Potassium voltage-gated channel subfamily KQT member 4 (KCNQ4)

Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea.

KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells where cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.

Gene Information

Human
Gene Name:	KCNQ4
Uniprot:	P56696
Entrez:	9132

Family

Belongs to:

potassium channel family

Alternative Names

DFNA2; DFNA2A; KQT-like 4; Kv7.4; potassium channel KQT-like 4; Potassium channel subunit alpha KvLQT4; potassium voltage-gated channel subfamily KQT member 4; potassium voltage-gated channel, KQT-like subfamily, member 4; Voltage-gated potassium channel subunit Kv7.4

Molecular Weight

Mass (kDA):
77.101 kDA

Genomic Context


Human

Location:	1p34.2
Sequence:	1; NC_000001.11 (40783787..40840457)

Tissue Specificity

Expressed in the outer, but not the inner, sensory hair cells of the cochlea. Slightly expressed in heart, brain and skeletal muscle.

Subcellular Localizations

Basal cell membrane; Multi-pass membrane protein. Situated at the basal membrane of cochlear outer hair cells.

Diseases

Complete Hearing Loss
Sensorineural Hearing Loss (disorder)
Epilepsy
Hearing Loss, High-frequency
Cardiac Arrhythmia
Nervousness
Deafness Congenital
Hypothyroidism
Hypertensive Disease
Convulsion Neonatal
Pain
Familial Benign Neonatal Epilepsy

Long Qt Syndrome
Neuralgia
Hearing Problem
Convulsions
Benign Neonatal Epilepsy
Cerebrovascular Accident
Presbycusis

Pathways

Transport
Localization
Secretion
Innervation
Aging
Regulation Of Gene Expression
Transepithelial Transport
Membrane Depolarization
Cognition
Gastric Acid Secretion
Cell Proliferation
Echolocation
Acid Secretion

Gene Silencing
Neurogenesis
Inner Ear Development
Developmental Maturation
Reflex
Reverse Transcription
Sensitization

PTMs

Phosphorylation
Biotinylation

Reduction
Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNQ4

References

PMID: 10025409 by Kubisch C., et al. KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness.

PMID: 10713961 by Selyanko A.A., et al. Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors.