KCNK1 Antibodies

AND KCNK1 ELISA kits, KCNK1 Proteins

Many biological assays use antibodies to detect KCNK1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNK1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNK1 antibodies...

We validate the specificity of these antibodies to KCNK1 by testing them on tissues known to express KCNK1 positively and negatively. Browse below to find the KCNK1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KCNK1 Infographic by Boster Bio

All KCNK1 Products

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Specificity

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Anti-KCNK1/Twik 1 Antibody

13 Q&As

Human, Rat

$360
Cat # A04502
100 µl

Anti-KCNK1 Antibody

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A04502-1
0.1 mg

KCNK1 (NM_002245) Human Over-expression Lysate

Human

$628
Cat # LS003775
100 µg

KCNK1 Overview

Facts about Potassium channel subfamily K member 1.

KCNK1 3D structure. Source: alphafold

Potassium channel subfamily K member 1 (KCNK1)

Ion channel which contributes to passive transmembrane potassium transport as well as the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PubMed:15820677, PubMed:21653227). Types dimeric channels through which potassium ions pass in accordance with their electrochemical gradient.

The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) in subphysiological K(+) levels and upon acidification of the extracellular medium (PubMed:21653227, PubMed:22431633). The homodimer has very low potassium channel activity, when expressed in heterologous systems, and may be weakly inward rectifying potassium channel (PubMed:8605869, PubMed:8978667, PubMed:15820677, PubMed:21653227, PubMed:22431633, PubMed:23169818, PubMed:25001086).

Gene Information

Human
Gene Name:	KCNK1
Uniprot:	O00180
Entrez:	3775

Family

Belongs to:

two pore domain potassium channel (TC 1.A.1.8) family

Alternative Names

DPK; HOHO1; Inward rectifying potassium channel protein TWIK-1; K2P1; K2p1.1; KCNO1; Potassium channel KCNO1; potassium channel subfamily K member 1; potassium channel, subfamily K, member 1; potassium inwardly-rectifying channel, subfamily K, member 1; TWIK-1; TWIK1HOHO

Molecular Weight

Mass (kDA):
38.143 kDA

Genomic Context


Human

Location:	1q42.2
Sequence:	1; NC_000001.11 (233614106..233672514)

Tissue Specificity

Detected in bronchial epithelial cells (PubMed:21964404). Detected in heart left atrium and left ventricle (PubMed:17478540). Detected in cardiac myocytes (at protein level) (PubMed:21653227). Widely expressed with high levels in heart, brain and kidney, and lower levels in colon, ovary, placenta, lung and liver (PubMed:8605869, PubMed:9362344). Highly expressed in cerebellum, and detected at lower levels in amygdala, caudate nucleus, brain cortex, hippocampus, putamen, substantia nigra, thalamus, dorsal root ganglion, spinal cord, pituitary, heart, kidney, lung, placenta, pancreas, stomach, small intestine, uterus and prostate (PubMed:11165377). Detected in right and left heart ventricle and atrium, and in heart Purkinje fibers (PubMed:17478540). Detected in bronchial epithelial cells (PubMed:21964404).

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Recycling endosome. Cell junction, synapse, synaptic cell membrane. Cytoplasmic vesicle. Perikaryon. Cell projection, dendrite. Cell projection. Apical cell membrane; Multi-pass membrane protein. The heterodimer with KCNK2 is detected at the astrocyte cell membrane. Not detected at the astrocyte cell membrane when KCNK2 is absent. Detected on neuronal cell bodies, and to a lesser degree on neuronal cell projections. Detected on hippocampus dentate gyrus granule cell bodies and to a lesser degree on proximal dendrites. Detected at the apical cell memb