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- Table of Contents
Facts about Potassium channel subfamily K member 3.
Acts as an external rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.
Human | |
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Gene Name: | KCNK3 |
Uniprot: | O14649 |
Entrez: | 3777 |
Belongs to: |
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two pore domain potassium channel (TC 1.A.1.8) family |
Acid-sensitive potassium channel protein TASK-1; cardiac potassium channel; K2p3.1; OAT1; potassium channel subfamily K member 3; potassium channel, subfamily K, member 3; potassium inwardly-rectifying channel, subfamily K, member 3; TASK1; TASK-1; TASKacid-sensitive potassium channel protein TASK; TBAK1; TWIK-related acid-sensitive K(+) channel 1; TWIK-related acid-sensitive K+ channel; two P domain potassium channel; Two pore K(+) channel KT3.1; Two pore potassium channel KT3.1
Mass (kDA):
43.518 kDA
Human | |
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Location: | 2p23.3 |
Sequence: | 2; NC_000002.12 (26692722..26733420) |
Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon.
Cell membrane; Multi-pass membrane protein.
PMID: 9312005 by Duprat F., et al. TASK, a human background K+ channel to sense external pH variations near physiological pH.
PMID: 10748056 by Lopes C.M.B., et al. Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3.