KCNJ4 Antibodies

AND KCNJ4 ELISA kits, KCNJ4 Proteins

Many biological assays use antibodies to detect KCNJ4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNJ4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNJ4 antibodies...

We validate the specificity of these antibodies to KCNJ4 by testing them on tissues known to express KCNJ4 positively and negatively. Browse below to find the KCNJ4 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KCNJ4 Infographic by Boster Bio

All KCNJ4 Products

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Product

Figures

Specificity

Applications

Price

Anti-KCNJ4/Kir2.3 Antibody

3 Q&As

Human, Mouse

$360
Cat # A06605
100 µl

Anti-KIR2.3 KCNJ4 Antibody

1 Q&As

Human, Mouse, Rat

$399
Cat # A06605-1
100μl

Anti-KCNJ4 Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A06605-2
100ul

KIR2.3 (KCNJ4) (NM_152868) Human Over-expression Lysate

Human

$960
Cat # LS003761
100 µg

KCNJ4 Overview

Facts about Inward rectifier potassium channel 4.

KCNJ4 3D structure. Source: alphafold

Inward rectifier potassium channel 4 (KCNJ4)

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages.

The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).

Gene Information

Human
Gene Name:	KCNJ4
Uniprot:	P48050
Entrez:	3761

Family

Belongs to:

inward rectifier-type potassium channel (TC 1.A.2.1) family

Alternative Names

hippocampal inward rectifier potassium channel; Hippocampal inward rectifier; HIRhIRK2; HIRK2; HRK1MGC142066; Inward rectifier K(+) channel Kir2.3; inward rectifier K+ channel Kir2.3; inward rectifier potassium channel 4; IRK-3; IRK3MGC142068; Kir2.3; Potassium channel, inwardly rectifying subfamily J member 4; potassium inwardly-rectifying channel, subfamily J, member 4

Molecular Weight

Mass (kDA):
49.5 kDA

Genomic Context


Human

Location:	22q13.1
Sequence:	22; NC_000022.11 (38426327..38455199, complement)

Tissue Specificity

Heart, skeletal muscle, and several different brain regions including the hippocampus.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane. TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 famaly members and KCNJ4 internalization.

Diseases

Cardiac Arrhythmia
Parkinson Disease
Nervousness
Hypercapnia
Atrial Fibrillation
Cardiac Fibrillation
Chimera Disorder
Ischemia
Nerve Degeneration
Heart Failure
Schizophrenia
Hypertensive Disease
Movement Disorders

Infarction
Chronic Atrial Fibrillation
Andersen Syndrome
Periodic Paralysis (finding)
Myocardial Infarction
Patient Dependence On
Exhaustion

Interacting Proteins

SCRIB

Pathways

Localization
Membrane Depolarization
Phagocytosis
Translation
Cellular Localization
Cell Death
Cellular Homeostasis
Synaptic Transmission

Neurogenesis
Endocytosis

PTMs

Phosphorylation

Reduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNJ4

References

PMID: 8016146 by Perier F., et al. Primary structure and characterization of a small-conductance inwardly rectifying potassium channel from human hippocampus.

PMID: 8034048 by Tang W., et al. Cloning a novel human brain inward rectifier potassium channel and its functional expression in Xenopus oocytes.