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KCNJ2 Antibodies
AND KCNJ2 ELISA kits, KCNJ2 Proteins
Many biological assays use antibodies to detect KCNJ2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNJ2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNJ2 antibodies...
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KCNJ2 Infographic by Boster Bio
All KCNJ2 Products
Product
Figures
Specificity
Applications
Price
Anti-Kir2.1 Rabbit Monoclonal Antibody
2 Citations
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M01850
100 μl/vial
Cat # M01850
100 μl/vial
KCNJ2 Overview
Facts about Inward rectifier potassium channel 2.
Inward rectifier potassium channel 2 (KCNJ2)
Probably participates in establishing action potential waveform and excitability of neuronal and muscle cells. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it.
Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
Gene Information
| Human | |
|---|---|
| Gene Name: | KCNJ2 |
| Uniprot: | P63252 |
| Entrez: | 3759 |
Family
| Belongs to: |
|---|
| inward rectifier-type potassium channel (TC 1.A.2.1) family |
Alternative Names
ATFB9; Cardiac inward rectifier potassium channel; HHBIRK1; HHIRK1; HIRK1; Inward rectifier K(+) channel Kir2.1; inward rectifier K+ channel KIR2.1; inward rectifier potassium channel 2; IRK1; IRK-1; IRK1LQT7; KCNJ2; Kir2.1; LQT7; Potassium channel, inwardly rectifying subfamily J member 2; potassium inwardly-rectifying channel, subfamily J, member 2; SQT3
Molecular Weight
Mass (kDA):
48.288 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q24.3 |
| Sequence: | 17; NC_000017.11 (70169532..70180044) |
Tissue Specificity
Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain.
Subcellular Localizations
Membrane; Multi-pass membrane protein. Membrane; Lipid-anchor.
Diseases
- Cardiac Arrhythmia
- Andersen Syndrome
- Periodic Paralysis (finding)
- Long Qt Syndrome
- Tachycardia, Ventricular
- Cardiac Fibrillation
- Atrial Fibrillation
- Sudden Death
- Sudden Cardiac Death
- Channelopathies
- Syncope
- Polymorphic Ventricular Tachycardia
Pathways
- Localization
- Pathogenesis
- Transport
- Translation
- Cell Proliferation
- Gene Silencing
- Aging
- Glycosylation
- Cardiac Conduction
- Cytokinesis
- Cell Division
- Membrane Depolarization
- Tooth Eruption
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNJ2
bosterbio.com/bosterbio-gene-info-cards/KCNJ2
References
PMID: 7696590 by Raab-Graham K.F., et al. Molecular cloning and expression of a human heart inward rectifier potassium channel.
PMID: 7590287 by Wood L.S., et al. Cloning and functional expression of a human gene, hIRK1, encoding the heart inward rectifier K+-channel.
2 Publications of Boster KCNJ2 Antibodies & ELISA Kits
- PubMed ID: 10.4314/tjpr.v17i3.5, Effect of pinocembrin pre-treatment on expressions of Cx43 protein and claudin 1...
- PubMed ID: 10.12659/MSM.909162, Effects of Pinocembrin Pretreatment on Connexin 43 (Cx43) Protein Expression Aft...
*More publications can be found for each product on its corresponding product page