KCNJ18 Antibodies

AND KCNJ18 ELISA kits, KCNJ18 Proteins

Many biological assays use antibodies to detect KCNJ18, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNJ18 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNJ18 antibodies...

We validate the specificity of these antibodies to KCNJ18 by testing them on tissues known to express KCNJ18 positively and negatively. Browse below to find the KCNJ18 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KCNJ18 Infographic by Boster Bio

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KCNJ18 Overview

Facts about Inward rectifier potassium channel 18.

KCNJ18 3D structure. Source: alphafold

Inward rectifier potassium channel 18 (KCNJ18)

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages.

The inward rectification is mainly due to the blockage of outward current by internal magnesium. .

Gene Information

Human
Gene Name:	KCNJ18
Uniprot:	B7U540
Entrez:	100134444

Family

Belongs to:

inward rectifier-type potassium channel (TC 1.A.2.1) family

Alternative Names

Inward rectifier potassium channel 18

Molecular Weight

Mass (kDA):
48.88 kDA

Genomic Context


Human

Location:	17p11.2
Sequence:	17; NC_000017.11 (21692523..21705700)

Tissue Specificity

Specifically expressed in skeletal muscle.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

Thyrotoxic periodic paralysis 2 (TTPP2)

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNJ18

References

PMID: 20074522 by Ryan D.P., et al. Mutations in potassium channel Kir2.6 cause susceptibility to thyrotoxic hypokalemic periodic paralysis.

PMID: 27008341 by Paninka R.M., et al. Whole genome and exome sequencing realignment supports the assignment of KCNJ12, KCNJ17, and KCNJ18 paralogous genes in thyrotoxic periodic paralysis locus: functional characterization of two polymorphic Kir2.6 isoforms.