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KCNJ10 Antibodies
AND KCNJ10 ELISA kits, KCNJ10 Proteins
Many biological assays use antibodies to detect KCNJ10, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNJ10 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNJ10 antibodies...
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KCNJ10 Overview
Facts about ATP-sensitive inward rectifier potassium channel 10.
ATP-sensitive inward rectifier potassium channel 10 (KCNJ10)
May cause potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it.
Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
Gene Information
| Human | |
|---|---|
| Gene Name: | KCNJ10 |
| Uniprot: | P78508 |
| Entrez: | 3766 |
Family
| Belongs to: |
|---|
| inward rectifier-type potassium channel (TC 1.A.2.1) family |
Alternative Names
ATP-dependent inwardly rectifying potassium channel Kir4.1; ATP-sensitive inward rectifier potassium channel 10; BIRK-10; glial ATP-dependent inwardly rectifying potassium channel KIR4.1; Inward rectifier K(+) channel Kir1.2; inward rectifier K+ channel KIR1.2; KCNJ13-PEN; KIR1.2; KIR4.1; Potassium channel, inwardly rectifying subfamily J member 10; potassium inwardly-rectifying channel, subfamily J, member 10; SESAME
Molecular Weight
Mass (kDA):
42.508 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q23.2 |
| Sequence: | 1; NC_000001.11 (160037467..160070160, complement) |
Tissue Specificity
Expressed in kidney (at protein level).
Subcellular Localizations
Membrane; Multi-pass membrane protein. Basolateral cell membrane. In kidney distal convoluted tubules, located in the basolateral membrane where it colocalizes with KCNJ16.
Diseases
- Complete Hearing Loss
- Sensorineural Hearing Loss (disorder)
- Epilepsy
- Ataxia
- Pendred's Syndrome
- Sesame Syndrome
- Alkalosis
- Deafness Congenital
- Electrolyte Imbalance
- Metabolic Alkalosis
- Epilepsy, Generalized
Interacting Proteins
- SIAH1
Pathways
- Transport
- Localization
- Secretion
- Ion Transport
- Ion Homeostasis
- Cell Death
- Pathogenesis
- Pigmentation
- Inner Ear Development
- Startle Response
- Reverse Transcription
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNJ10
bosterbio.com/bosterbio-gene-info-cards/KCNJ10
References
PMID: 8995301 by Shuck M.E., et al. Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3).
PMID: 10659995 by Schoots O., et al. Co-expression of human Kir3 subunits can yield channels with different functional properties.