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KCNJ11 Antibodies
AND KCNJ11 ELISA kits, KCNJ11 Proteins
Many biological assays use antibodies to detect KCNJ11, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNJ11 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNJ11 antibodies...
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KCNJ11 Infographic by Boster Bio
All KCNJ11 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA
$480
Cat # EKC1331
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1331
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse
ELISA
$540
Cat # EKC2306
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2306
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00795T224
100ul
Cat # A00795T224
100ul
KCNJ11 Overview
Facts about ATP-sensitive inward rectifier potassium channel 11.
ATP-sensitive inward rectifier potassium channel 11 (KCNJ11)
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it.
Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
Gene Information
| Human | |
|---|---|
| Gene Name: | KCNJ11 |
| Uniprot: | Q14654 |
| Entrez: | 3767 |
Family
| Belongs to: |
|---|
| inward rectifier-type potassium channel (TC 1.A.2.1) family |
Alternative Names
ATP-sensitive inward rectifier potassium channel 11; beta-cell inward rectifier subunit; BIRKIR6.2; HHF2; IKATP; Inward rectifier K(+) channel Kir6.2; inwardly rectifying potassium channel KIR6.2; Kir6.2; MGC133230; PHHI; potassium channel inwardly rectifing subfamily J member 11; Potassium channel, inwardly rectifying subfamily J member 11; potassium inwardly-rectifying channel, subfamily J, member 11; TNDM3
Molecular Weight
Mass (kDA):
43.541 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p15.1 |
| Sequence: | 11; NC_000011.10 (17385246..17389346, complement) |
Subcellular Localizations
Membrane; Multi-pass membrane protein.
Diseases
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Hyperinsulinism
- Hypoglycemia
- Persistent Hyperinsulinemia Hypoglycemia Of Infancy
- Diabetes Mellitus, Insulin-dependent
- Developmental Delay (disorder)
- Epilepsy
- Hyperglycemia
- Insulin Resistance
- Obesity
- Impaired Glucose Tolerance
Interacting Proteins
- ANK2
Pathways
- Secretion
- Insulin Secretion
- Pathogenesis
- Glucose Homeostasis
- Regulation Of Insulin Secretion
- Transport
- Translation
- Methylation
- Exocytosis
- Fatty Acid Oxidation
- Dna Methylation
- Glomerular Filtration
- Regeneration
PTMs
- Methylation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNJ11
bosterbio.com/bosterbio-gene-info-cards/KCNJ11
References
PMID: 7502040 by Inagaki N., et al. Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor.
PMID: 9831708 by Babenko A.P., et al. Reconstituted human cardiac KATP channels: functional identity with the native channels from the sarcolemma of human ventricular cells.