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KCNJ1 Antibodies
AND KCNJ1 ELISA kits, KCNJ1 Proteins
Many biological assays use antibodies to detect KCNJ1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNJ1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNJ1 antibodies...
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KCNJ1 Overview
Facts about ATP-sensitive inward rectifier potassium channel 1.
ATP-sensitive inward rectifier potassium channel 1 (KCNJ1)
In the liver, likely plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it.
Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
Gene Information
| Human | |
|---|---|
| Gene Name: | KCNJ1 |
| Uniprot: | P48048 |
| Entrez: | 3758 |
Family
| Belongs to: |
|---|
| inward rectifier-type potassium channel (TC 1.A.2.1) family |
Alternative Names
ATP-regulated potassium channel ROM-K; ATP-sensitive inward rectifier potassium channel 1; inwardly rectifying K+ channel; KIR1.1; potassium inwardly-rectifying channel, subfamily J, member 1; ROMK1inwardly rectifying subfamily J member 1
Molecular Weight
Mass (kDA):
44.795 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q24.3 |
| Sequence: | 11; NC_000011.10 (128838020..128867296, complement) |
Tissue Specificity
In the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane.
Diseases
- Bartter Disease
- Disease Of Adrenal Medulla
- Alkalosis
- Hypertensive Disease
- Metabolic Alkalosis
- Gitelman Syndrome
- Hypercalciuria
- Pseudohypoaldosteronism
- Nephrocalcinosis
- Cystic Fibrosis
- Fibrosis
- Polyhydramnios
Pathways
- Secretion
- Transport
- Excretion
- Localization
- Endocytosis
- Ion Transport
- Pathogenesis
- Glycosylation
- Renal Potassium Excretion
- Translation
- Water Transport
- Glomerular Filtration
- Diuresis
PTMs
- Phosphorylation
- Glycosylation
- Dephosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNJ1
bosterbio.com/bosterbio-gene-info-cards/KCNJ1
References
PMID: 7929082 by Shuck M.E., et al. Cloning and characterization of multiple forms of the human kidney ROM-K potassium channel.
PMID: 8190102 by Yano H., et al. Alternative splicing of human inwardly rectifying K+ channel ROMK1 mRNA.