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- Table of Contents
Facts about Potassium voltage-gated channel subfamily H member 2.
Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (PubMed:18559421, PubMed:26363003, PubMed:27916661). .
Human | |
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Gene Name: | KCNH2 |
Uniprot: | Q12809 |
Entrez: | 3757 |
Belongs to: |
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potassium channel family |
Eag homolog; Eag-related protein 1; ERG; erg1; ERG-1; Ether-a-go-go-related gene potassium channel 1; ether-a-go-go-related potassium channel protein; Ether-a-go-go-related protein 1; H-ERG; HERG1; HERGhERG-1; Kv11.1; LQT2; potassium voltage-gated channel subfamily H member 2; potassium voltage-gated channel, subfamily H (eag-related), member 2; SQT1; Voltage-gated potassium channel subunit Kv11.1
Mass (kDA):
126.655 kDA
Human | |
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Location: | 7q36.1 |
Sequence: | 7; NC_000007.14 (150944956..150978321, complement) |
Highly expressed in heart and brain. Isoforms USO are frequently overexpressed in cancer cells.
Cell membrane; Multi-pass membrane protein.
PMID: 8159766 by Warmke J.W., et al. A family of potassium channel genes related to eag in Drosophila and mammals.
PMID: 9600240 by Itoh T., et al. Genomic organization and mutational analysis of HERG, a gene responsible for familial long QT syndrome.