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- Table of Contents
Facts about Potassium voltage-gated channel subfamily H member 1.
Mediates IK(NI) present in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, specifically adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642).
Human | |
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Gene Name: | KCNH1 |
Uniprot: | O95259 |
Entrez: | 3756 |
Belongs to: |
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potassium channel family |
EAG channel 1; EAG1; EAGeag1; Ether-a-go-go potassium channel 1; ether-a-go-go, Drosophila, homolog of; hEAG1; h-eageag; Kv10.1; MGC142269; potassium channel, voltage-gated, subfamily H, member 1; potassium voltage-gated channel subfamily H member 1; potassium voltage-gated channel, subfamily H (eag-related), member 1; Voltage-gated potassium channel subunit Kv10.1
Mass (kDA):
111.423 kDA
Human | |
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Location: | 1q32.2 |
Sequence: | 1; NC_000001.11 (210678314..211134148, complement) |
Highly expressed in brain and in myoblasts at the onset of fusion, but not in other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7 (epithelial tumor) cells, but not in normal epithelial cells.
Cell membrane; Multi-pass membrane protein. Nucleus inner membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, axon. Cell junction, synapse, presynaptic cell membrane. Perikaryon. Cell junction, synapse, postsynaptic density membrane. Early endosome membrane. Perinuclear KCNH1 is located to NPC-free islands.
PMID: 9738473 by Occhiodoro T., et al. Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion.
PMID: 10523298 by Pardo L.A., et al. Oncogenic potential of EAG K(+) channels.