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- Table of Contents
Facts about Potassium voltage-gated channel subfamily E member 2.
Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is suggested to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr).
Human | |
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Gene Name: | KCNE2 |
Uniprot: | Q9Y6J6 |
Entrez: | 9992 |
Belongs to: |
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potassium channel KCNE family |
ATFB4; cardiac voltage-gated potassium channel accessory subunit 2; human minK-related peptide 1, potassium channel subunit, MiRP110Minimum potassium ion channel-related peptide 1; LQT5; LQT6; MGC138292; MinK-related peptide 1; minK-related peptide-1; MIRP1; Potassium channel subunit beta MiRP1; potassium channel subunit, MiRP1; potassium voltage-gated channel subfamily E member 2; potassium voltage-gated channel, Isk-related family, member 2; voltage-gated K+ channel subunit MIRP1
Mass (kDA):
14.472 kDA
Human | |
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Location: | 21q22.11 |
Sequence: | 21; NC_000021.9 (34364024..34371141) |
Highly expressed in brain, heart, skeletal muscle, pancreas, placenta, kidney, colon and thymus. A small but significant expression is found in liver, ovary, testis, prostate, small intestine and leukocytes. Very low expression, nearly undetectable, in lung and spleen.
Cell membrane; Single-pass type I membrane protein. Colocalizes with KCNB1 at the plasma membrane.
PMID: 10219239 by Abbott G.W., et al. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia.
PMID: 11034315 by Tinel N., et al. M-type KCNQ2-KCNQ3 potassium channels are modulated by the KCNE2 subunit.