CASP8AP2 Antibodies

AND CASP8AP2 ELISA kits, CASP8AP2 Proteins

Many biological assays use antibodies to detect CASP8AP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CASP8AP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CASP8AP2 antibodies...

We validate the specificity of these antibodies to CASP8AP2 by testing them on tissues known to express CASP8AP2 positively and negatively. Browse below to find the CASP8AP2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CASP8AP2 Infographic by Boster Bio

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Anti-FLASH CASP8AP2 Antibody

Human

ELISA, IF, ICC, WB

$449
Cat # A03925
0.1 mg

CASP8AP2 Overview

Facts about CASP8-associated protein 2.

CASP8AP2 3D structure. Source: alphafold

CASP8-associated protein 2 (CASP8AP2)

Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF- kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation.

Involved in TNF-alpha-induced activation of NF-kappa-B Using a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B.

Gene Information

Human
Gene Name:	CASP8AP2
Uniprot:	Q9UKL3
Entrez:	9994

Family

Belongs to:

No superfamily

Alternative Names

CASP8 associated protein 2; caspase 8 associated protein 2; CED-4; FLASHKIAA1315CASP8-associated protein 2; FLICE associated huge; FLICE-associated huge protein; FLJ11208; human FLASH; RIP25FLASH homolog RIP25

Molecular Weight

Mass (kDA):
222.658 kDA

Genomic Context


Human

Location:	6q15
Sequence:	6; NC_000006.12 (89829880..89874436)

Subcellular Localizations

Cytoplasm. Nucleus. Nucleus, PML body. Mitochondrion. Exported from the nucleus to the mitochondria upon FAS activation.

Diseases

Malignant Neoplasms
Leukemia
Neoplasms
Acute Lymphocytic Leukemia
Carcinoma
Neoplasm, Residual
L1 Acute Lymphoblastic Leukemia
Colorectal Neoplasms
Myocardial Infarction
Colorectal Cancer
Anoxia
Cell Transformation, Neoplastic
Malignant Neoplasm Of Stomach

Hypoxia
Myeloid Leukemia
Lymphoma
Precursor T-cell Lymphoblastic Leukemia-lymphoma
Ataxia Telangiectasia
Infarction
Sclerosis

Interacting Proteins

CASP8
PIAS1
SP100

Pathways

Cell Cycle
Localization
Cell Death
Pathogenesis
Cell Differentiation
Dna Methylation
Methylation
S Phase
Rna Interference
Transport
Muscle Cell Differentiation
Cell Cycle Phase
Stem Cell Differentiation

Apoptosome Assembly
Response To Uv-c
Protein Sumoylation
Regulation Of Gene Expression
Nuclear Export
Cell Division
Cell Motility

PTMs

Cleavage
Methylation

Sumoylation
Demethylation

Research Areas

Apoptosis
Cancer
Tumor Suppressors

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CASP8AP2

References

PMID: 10537104 by Koonin E.V., et al. Apoptosis. Searching for FLASH domains.

PMID: 12477726 by Kino T., et al. Tumor necrosis factor alpha receptor- and Fas-associated FLASH inhibit transcriptional activity of the glucocorticoid receptor by binding to and interfering with its interaction with p160 type nuclear receptor coactivators.