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- Table of Contents
Facts about Potassium voltage-gated channel subfamily A member 6.
The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2347305, PubMed:14575698). Can form operational homotetrameric channels and heterotetrameric channels which contain varying proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members too; channel properties depend on the type of alpha subunits which are part of the channel (By similarity).
Human | |
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Gene Name: | KCNA6 |
Uniprot: | P17658 |
Entrez: | 3742 |
Belongs to: |
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potassium channel family |
FLJ25134; HBK2; human brain potassium channel-2; KV1.6; potassium voltage-gated channel subfamily A member 6; potassium voltage-gated channel, shaker-related subfamily, member 6; Voltage-gated potassium channel HBK2; voltage-gated potassium channel protein Kv1.6; Voltage-gated potassium channel subunit Kv1.6
Mass (kDA):
58.729 kDA
Human | |
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Location: | 12p13.32 |
Sequence: | 12; NC_000012.12 (4806877..4851927) |
Cell membrane; Multi-pass membrane protein.
PMID: 2347305 by Grupe A., et al. Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family.
PMID: 14575698 by Guihard G., et al. Human Kv1.6 current displays a C-type-like inactivation when re- expressed in cos-7 cells.