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- Table of Contents
1 Citations 5 Q&As
Facts about Potassium voltage-gated channel subfamily A member 1.
The station alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772). Can form practical homotetrameric channels and heterotetrameric channels that contain varying proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other relatives as well; station properties are based on the sort of alpha subunits that are part of the station (PubMed:12077175, PubMed:17156368).
Human | |
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Gene Name: | KCNA1 |
Uniprot: | Q09470 |
Entrez: | 3736 |
Belongs to: |
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potassium channel family |
AEMK; EA1; HBK1; HUK1; Kv1.1; MBK1; MGC126782; MGC138385; MK1; potassium voltage-gated channel subfamily A member 1; potassium voltage-gated channel, shaker-related subfamily, member 1 (episodicataxia with myokymia); RBK1; Voltage-gated K(+) channel HuKI; Voltage-gated potassium channel HBK1; Voltage-gated potassium channel subunit Kv1.1
Mass (kDA):
56.466 kDA
Human | |
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Location: | 12p13.32 |
Sequence: | 12; NC_000012.12 (4909905..4918256) |
Detected adjacent to nodes of Ranvier in juxtaparanodal zones in spinal cord nerve fibers, but also in paranodal regions in some myelinated spinal cord axons (at protein level) (PubMed:11086297). Detected in the islet of Langerhans (PubMed:21483673).
Cell membrane; Multi-pass membrane protein. Membrane. Cell projection, axon. Cytoplasmic vesicle. Perikaryon. Endoplasmic reticulum. Cell projection, dendrite. Cell junction. Cell junction, synapse. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, presynapse. Homotetrameric KCNA1 is primarily located in the endoplasmic reticulum. Interaction with KCNA2 and KCNAB2 or with KCNA4 and KCNAB2 promotes expression at the cell membrane (By similarity).
PMID: 19912772 by Ramaswami M., et al. Human potassium channel genes: molecular cloning and functional expression.
PMID: 2128063 by Freeman S.N., et al. Cloning and characterization of a cDNA encoding a human brain potassium channel.
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