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- Table of Contents
Facts about KN motif and ankyrin repeat domain-containing protein 2.
May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; suggested to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus (PubMed:22371500).
Human | |
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Gene Name: | KANK2 |
Uniprot: | Q63ZY3 |
Entrez: | 25959 |
Belongs to: |
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No superfamily |
ANKRD25; ankyrin repeat domain 25; Ankyrin repeat domain-containing protein 25; DKFZp434N161; FLJ20004; KIAA1518SRC1-interacting protein; kidney ankyrin repeat-containing protein 2; KN motif and ankyrin repeat domain-containing protein 2; KN motif and ankyrin repeat domains 2; Matrix-remodeling-associated protein 3; matrix-remodelling associated 3; MGC119707; MXRA3; SIP; SRC-1 interacting protein; SRC-1-interacting protein
Mass (kDA):
91.174 kDA
Human | |
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Location: | 19p13.2 |
Sequence: | 19; NC_000019.10 (11164267..11197545, complement) |
Strongly expressed in cervix, colon, heart, kidney and lung. Expressed in kidney glomerular podocytes and mesangial cells (at protein level).
Cytoplasm. Mitochondrion.
PMID: 17476305 by Zhang Y., et al. SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm.
PMID: 17996375 by Zhu Y., et al. Kank proteins: a new family of ankyrin-repeat domain-containing proteins.