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- Table of Contents
Facts about Junction plakoglobin.
The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells.
Human | |
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Gene Name: | JUP |
Uniprot: | P14923 |
Entrez: | 3728 |
Belongs to: |
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beta-catenin family |
catenin (cadherin-associated protein), gamma (80kD); catenin (cadherin-associated protein), gamma 80kDa; Catenin gamma; Desmoplakin III; desmoplakin-3; DP3CTNNG; DPIII; gamma-catenin; junction plakoglobin; PDGBARVD12; PKGB
Mass (kDA):
81.745 kDA
Human | |
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Location: | 17q21.2 |
Sequence: | 17; NC_000017.11 (41754607..41786768, complement) |
Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Cytoplasmic in a soluble and membrane-associated form.
PMID: 2726765 by Franke W.W., et al. Molecular cloning and amino acid sequence of human plakoglobin, the common junctional plaque protein.
PMID: 11016852 by Whittock N.V., et al. Genomic organization and amplification of the human plakoglobin gene (JUP).