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- Table of Contents
Facts about Jun dimerization protein 2.
Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN.
Mouse | |
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Gene Name: | Jdp2 |
Uniprot: | P97875 |
Entrez: | 81703 |
Belongs to: |
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bZIP family |
Jun dimerization protein 2; JUNDM2; progesterone receptor co-activator
Mass (kDA):
18.675 kDA
Mouse | |
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Location: | 12|12 D2 |
Sequence: | 12; |
Ubiquitously expressed in all adult tissues tested as well in embryos.
We will be discussing the history of Steven Boster and primary antibodies. We'll also discuss ELISA as well as primary antibodies and the importance Boster bio products in research. Boster is a trusted name in the research community, and our antibodies have been validated in ELISA, Western Blotting, and Immunohistochemistry.
Steven Boster's legacy is filled with the legends of JDP2 marker. The son of Evelyn Meier and James Boster, Steve worked for many years in retail sales. He was also a proud Concordia Hall member in Staunton, VA. Two sisters, Kimberly Blanton, Tammy Boster and brother Jack Boster were his other siblings. Many nieces & nephews also survived him.
The function of the JDP2 marker is still unclear. It is involved the activation of antioxidant gene and the Nrf2/MafK combination. It can also promote transcription. Its role in aging or oxidative stresses is unknown. However, it is believed to have anticancer benefits. It may also be useful in the regulation p16Ink4a/p19Arf.
JDP2 inhibition has been linked to F9 cells' RA-induced differentiation. JDP2 inhibits cjun transcription, and direct repressions other RA-inducible genetic genes. The marker may regulate the expression of differentiation marks. This could provide insight into the cellular mechanisms responsible for regulating RA. JDP2, a gene that may regulate RA, could be one of these.
Researchers discovered that JDP2 can function in conjunction with HDAC3 in a recent study. This association prompted researchers from the University of California to discover a gene called HDAC3 also associated with JDP2.
Recent research also suggests that JDP2 may be linked to the development and maintenance of atrial defects in mice. JDP2 could also be responsible for the absence of ventricular defects. JDP2 may also be associated with the development and maintenance of atrial defects. However, it is not known if the JDP2 genes is essential for a specific disease in humans.
While there are still many unknowns about the role of JDP2 in tumor metastaticity, it has been established that this gene is important. JDP2 expression is a key factor in tumor cells' ability to migrate and metastasize to distant organs. MMP9 does not play a role in the inflammatory response caused by JDP2 protein. However, other factors may be involved. It is important to understand the role of this protein in cancer progression.
JDP2 is not yet implicated in cancer, but it was identified as a candidate gene in high-throughput screenings of tumors. Its overexpression in cancer cells was associated with a larger tumor in transgenic mice. JDP2 plays a dual role in cancer progression. A better understanding of its role is necessary before determining if it is a tumour marker.
RT-PCR using the JDP2 gene marker was used to detect multiple Jdp2 mRNA isoforms. This marker can be found downstream of two AUG codes. These chimeric transcripts can be related to intragenic provirus inserts. These findings were confirmed using two separate mouse models for human leukemia. These results support our hypothesis that multiple Jdp2 may exist.
To further investigate the role of Jdp2 in leukemia, we performed western blot analyses on tissue samples from BALB/c mice. We used polyclonal antibody against Jdp2 as well as anti-histoneH2B to assess the protein loading in these experiments. We found that the highest signal level was in skeletal muscles, followed closely by liver, heart, testis and the heart. The liver and heart had the smaller Jdp2 bands.
RT-PCR with JDP2 gene markers reveals the presence in tumors of the intron 2. This marker was identified by 5' RACE. It uses a reverse primer in Jdp2 or Actb exon 3. The alternative Jdp2 e-1/k exons are shown in normal and tumor tissues. It is also possible to indicate the exact positions of exon 1-specific splice donors sites.
The results of RTPCR with JDP2 gene markers were highly positive in the absence of PDE4B down. The effects of the oxidative stress were partially reversed partly by Jdp2's overexpression. Jdp2 overexpression also reversed the effects from the PDE4B downregulation. Jdp2 overexpression decreased the effects of the LDH and H/R treatments on H9c2 cell H9c2 cells when Actb was absent.
The positive results of the paired RRT-PCR tests confirmed the positive result in a 421-infected specimen study. The New RT-PCR also produced a 95% CI for the infected specimens. It was 100% specific when it was used with lower respiratory specimens. These results prove the usefulness of this test to diagnose viral infections. This rRTPCR test can be used in many other ways.
Boster Bio offers high-affinity primary antibodies that have been validated for Western Blotting, Immunohistochemistry, and ELISA. They are derived using proprietary trade secrets and can be purchased as 100ul Liquids or lyophilized antibodies solutions. In the ELISA format, Boster antibodies react with Human. Boster Bio anti KHDRBS2 antibodies can be purchased in 100ul Liquid and are highly effective in the detection of this protein from a variety of samples.
Monoclonal antibody are created by immunizing the host using an antigen. They contain the complementarity determining region of the proteins, which is an interesting topic. Wikipedia has more information about complementarity-determining areas. Scientists immunize host animal with a variety o antigens, and then collect the antigen-specific antibody from their sera or eggs.
Dual-labeling specimens with primary-secondary antibodies allows researchers to ask more questions using fewer specimens. Dual-labeling antibodies may also be able to provide more detailed, robust answers and context data. Researchers can analyze a variety of genetic and pathological disorders using the Boster Bio JDP2 Marker in conjunction with the primary antibody of the JDP2 Antigen.
PMID: 12707301 by Kawaida R., et al. Jun dimerization protein 2 (JDP2), a member of the AP-1 family of transcription factor, mediates osteoclast differentiation induced by RANKL.
PMID: 11231009 by Jin C., et al. Identification of mouse Jun dimerization protein 2 as a novel repressor of ATF-2.