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IRF3 Antibodies
AND IRF3 ELISA kits, IRF3 Proteins
Many biological assays use antibodies to detect IRF3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IRF3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IRF3 antibodies...
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IRF3 Infographic by Boster Bio
All IRF3 Products
Product
Figures
Specificity
Applications
Price
Anti-Interferon regulatory factor 3 IRF3 Antibody
1 Citations 16 Q&As
Human
WB
$370
Cat # PA1819
100 μg/vial
Cat # PA1819
100 μg/vial
Anti-IRF3 Rabbit Monoclonal Antibody
1 Citations 5 Q&As
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00165
100 μl
Cat # M00165
100 μl
Human
ELISA
$480
Cat # EKC1308
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1308
1 kit, containing one 96-well plate and all necessary reagents
Human
ELISA
$540
Cat # EKC2078
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2078
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2154
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2154
1 kit, containing two 96-well plates and all necessary reagents
Human
ELISA
$540
Cat # EKC2585
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2585
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse
ELISA, IF, IHC-P, WB
$449
Cat # A00165
0.1 mg
Cat # A00165
0.1 mg
Human, Rat
ELISA, IF, ICC, WB
$449
Cat # A00165-1
0.1 mg
Cat # A00165-1
0.1 mg
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$405
Cat # A00165-3
100ul
Cat # A00165-3
100ul
Mouse
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00165-5
100 μg/vial
Cat # A00165-5
100 μg/vial
Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # M00165-2
100 μg/vial
Cat # M00165-2
100 μg/vial
Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # M00165-3
100 μg/vial
Cat # M00165-3
100 μg/vial
Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # M00165-4
100 μg/vial
Cat # M00165-4
100 μg/vial
Human, Mouse
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00165-6
100 μg/vial
Cat # A00165-6
100 μg/vial
Human
Flow Cytometry, IF, IHC, WB
$523
Cat # M00165-6
100 µl
Cat # M00165-6
100 µl
Human, Monkey
IHC, WB
$523
Cat # M00165-1
100 µl
Cat # M00165-1
100 µl
IRF3 Overview
Facts about Interferon regulatory factor 3.
Interferon regulatory factor 3 (IRF3)
Essential transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters.
Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late stages of the IFNA/B gene induction. Located in an inactive form in the cytoplasm of uninfected cells and after viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases.
Gene Information
| Human | |
|---|---|
| Gene Name: | IRF3 |
| Uniprot: | Q14653 |
| Entrez: | 3661 |
Family
| Belongs to: |
|---|
| IRF family |
Alternative Names
interferon regulatory factor 3; IRF3; IRF-3
Molecular Weight
Mass (kDA):
47.219 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.33 |
| Sequence: | 19; NC_000019.10 (49659569..49665875, complement) |
Tissue Specificity
Expressed constitutively in a variety of tissues.
Subcellular Localizations
Cytoplasm. Nucleus. Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect (PubMed:10805757). When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm (PubMed:10805757).
Diseases
- Virus Diseases
- Innate Immune Response
- Infective Disorder
- Inflammation
- Hepatitis
- Hepatitis C
- Influenza
- Vesicular Stomatitis
- Stomatitis
- Neoplasms
- Melanoma
- Malignant Neoplasms
Interacting Proteins
- CREBBP
- GRIP1
- IKBKE
- MAFB
- RB1
- RBL1
- RIOK3
- SGTA
- TBK1
Pathways
- Immune Response
- Innate Immune Response
- Pathogenesis
- Secretion
- Viral Replication
- Virulence
- Localization
- Cytokine Production
- Rna Interference
- Cell Death
- Inflammatory Response
- Response To Virus
- Type I Interferon Production
PTMs
- Phosphorylation
- Ubiquitination
- Cleavage
- Acetylation
- Methylation
- Deacetylation
- Sumoylation
- Isgylation
Research Areas
- Immunology
- Innate Immunity
- Phospho-Specific
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IRF3
bosterbio.com/bosterbio-gene-info-cards/IRF3
References
PMID: 8524823 by Au W.W.-C., et al. Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes.
PMID: 9803267 by Bellingham J., et al. Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker.
1 Publications of Boster IRF3 Antibodies & ELISA Kits
- PubMed ID: 27164829, Curcumin exerts anti-inflammatory and antioxidative properties in 1-methyl-4-phe...
*More publications can be found for each product on its corresponding product page