INPP5E Antibodies

AND INPP5E ELISA kits, INPP5E Proteins

Many biological assays use antibodies to detect INPP5E, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with INPP5E in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop INPP5E antibodies...

We validate the specificity of these antibodies to INPP5E by testing them on tissues known to express INPP5E positively and negatively. Browse below to find the INPP5E antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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INPP5E Infographic by Boster Bio

All INPP5E Products

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Product

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Specificity

Applications

Price

Anti-INP5E INPP5E Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A05973
100ul

INPP5E (NM_019892) Human Over-expression Lysate

Human

$628
Cat # LS056623
100 µg

INPP5E Overview

Facts about Phosphatidylinositol polyphosphate 5-phosphatase type IV.

INPP5E 3D structure. Source: alphafold

Phosphatidylinositol polyphosphate 5-phosphatase type IV (INPP5E)

Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) into PtdIns-P2, and phosphatidylinositol 4,5- bisphosphate into phosphatidylinositol 4-phosphate. Particular for lipid substrates, inactive towards water soluble inositol phosphates.

Gene Information

Human
Gene Name:	INPP5E
Uniprot:	Q9NRR6
Entrez:	56623

Family

Belongs to:

inositol 1,4,5-trisphosphate 5-phosphatase type IV family

Alternative Names

CORS172 kDa inositol polyphosphate 5-phosphatase; CPD4; EC 3.1.3.36; inositol polyphosphate-5-phosphatase, 72 kDa; JBTS1; Joubert syndrome 1; MGC117201; MORMS; phosphatidylinositol (4,5) bisphosphate 5-phosphatase; Phosphatidylinositol polyphosphate 5-phosphatase type IV; Phosphatidylinositol-4,5-bisphosphate 5-phosphatase; PPI5PIV

Molecular Weight

Mass (kDA):
70.205 kDA

Genomic Context


Human

Location:	9q34.3
Sequence:	9; NC_000009.12 (136428619..136439861, complement)

Tissue Specificity

Detected in brain, heart, pancreas, testis and spleen.

Subcellular Localizations

Cytoplasm, cytoskeleton, cilium axoneme. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle. Cytoplasm. Peripheral membrane protein associated with Golgi stacks.

Diseases

Familial Aplasia Of The Vermis
Oculocerebrorenal Syndrome
Malignant Neoplasms
Neoplasms
Bardet-biedl Syndrome
Nephronophthisis
Abnormal Degeneration
Polydactyly
Diabetes Mellitus
Insulin Resistance
Meckel-gruber Syndrome
Leukemia

Retinal Dystrophies
Microphthalmos
Mutation, Out-of-frame
Malignant Neoplasm Of Breast
Ataxia
Fibrosis
Oculomotor Apraxia

Pathways

Cell Proliferation
Endocytosis
Glucose Homeostasis
Cell Migration
Phagocytosis
Cell Death
Localization

Regulation Of Embryonic Development

PTMs

Phosphorylation
Dephosphorylation

Prenylation
Ribosylation

Research Areas

Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/INPP5E

References

PMID: 10764818 by Kisseleva M.V., et al. The isolation and characterization of a cDNA encoding phospholipid- specific inositol polyphosphate 5-phosphatase.

PMID: 19668215 by Jacoby M., et al. INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse.