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- Table of Contents
1 Citations 4 Q&As
3 Citations 9 Q&As
1 Citations 7 Q&As
Facts about Interleukin-23 receptor.
IL23 functions in innate and adaptive immunity and might take part in acute response to infection in peripheral tissues. IL23 might cause autoimmune inflammatory diseases and be important for tumorigenesis.
Human | |
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Gene Name: | IL23R |
Uniprot: | Q5VWK5 |
Entrez: | 149233 |
Belongs to: |
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type I cytokine receptor family |
IBD17; IL-23 R; IL-23 receptor; IL23R; IL-23R; interleukin 23 receptor; interleukin-23 receptor
Mass (kDA):
71.722 kDA
Human | |
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Location: | 1p31.3 |
Sequence: | 1; NC_000001.11 (67138639..67259979) |
Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.
Cell membrane; Single-pass type I membrane protein.
PMID: 12023369 by Parham C., et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL- 12Rbeta1 and a novel cytokine receptor subunit, IL-23R.
PMID: 16372191 by Zhang X.-Y., et al. Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells.
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