IL23A Antibodies

Interleukin-23 subunit alpha (IL23A)

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues.

IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory as opposed to naive T- cells and boosts production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may cause autoimmune inflammatory diseases and may be important for tumorigenesis.

Gene Information

Human
Gene Name:	IL23A
Uniprot:	Q9NPF7
Entrez:	51561

Family

Belongs to:
IL-6 superfamily

Alternative Names

IL-23 p19/IL-12 p40; IL23; IL-23; IL-23A; IL-23-A; IL-23p19; IL-23p19/IL-12p40; IL23P19P19; interleukin 23 p19 subunit; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; Interleukin-23 subunit p19; JKA3 induced upon T-cell activation; MGC79388; SGRF; SGRFIL-23 subunit alpha

Molecular Weight

Mass (kDA):
20.73 kDA

Genomic Context

Human
Location:	12q13.3
Sequence:	12; NC_000012.12 (56334159..56340410)

Tissue Specificity

Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).

Subcellular Localizations

Secreted. Secreted upon association with IL12B.

Diseases

• Inflammation
• Autoimmune Reaction
• Autoimmune Diseases
• Neoplasms
• Autoimmunity
• Experimental Autoimmune Encephalomyelitis
• Arthritis
• Psoriasis
• Encephalomyelitis
• Infective Disorder
• Tuberculosis
• Multiple Sclerosis
• Salmonella Infections

• Sclerosis
• Inflammatory Bowel Diseases
• Mycobacterium Infections
• Crohn Disease
• Colitis
• Intestinal Diseases
• Nervousness

Interacting Proteins

• IL12B
• PEX19

Pathways

• Immune Response
• Pathogenesis
• Secretion
• Cytokine Production
• Cell Activation
• Interferon-gamma Production
• Inflammatory Response
• Cell Differentiation
• Hypersensitivity
• Reverse Transcription
• Translation
• Granuloma Formation
• Cell Proliferation

• Cell Development
• Angiogenesis
• T Cell Activation
• Virulence
• Phagocytosis
• T Cell Proliferation
• Innate Immune Response

PTMs

• Phosphorylation
• Glycosylation

• Cleavage
• Deacetylation

• Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL23A

Boster Bio - Best Uses Of The IL23A Marker

Continue reading to learn more about Boster Bio's Anti IL2RA antibody. This article will provide you with information about the benefits and uses of this product. You'll also find out about Boster's validation procedures, and the reason why it's crucial to review the antibody for specificity and affinity. You can also earn product credits for reviewing Boster products, and also receive free boster antibodies when you review the products.

Boster Bio Anti-IL2RA Antibody

The Boster Bio Anti-IL2RA Antibody reacts with human IL2RA protein. The antibody must be stored at 20°C or frozen for up to six months. It is composed of 5 mg BSA and 0.05 mg NaN3. It can also be purchased as an inhibitory peptide. The antibodies are tested by Boster Bio on positive and negative samples.

The GBSI Antibody Standards Committee will concentrate on developing common standards for affinity reagents. The committee will involve scientists in the development and application of guidelines for antibody suppliers. The Antibody Society and the Human Proteome Organization are hosting workshops for researchers to discover how to utilize antibodies and reagents. The goal is to ensure the quality and safety of antibodies.

The clone FN50 was identified by using Pacific Blue and PE conjugated mAb. The clone HI149 was identified using FITC-conjugated mAb. In the mouse experiment, BD Biosciences provided the PE-Cy7 mAb that is anti-murine, and the clone M1/70 and PD-L1 mAb were obtained from AbD Serotec.

The 26th International Conference on Antibody Engineering & Therapeutics was held in San Diego, California, between 6 and December. More than 800 scientists from around the world attended the conference that covered a variety of aspects of antibody engineering as well as the development of biologics. The pre-conference training course focused on the engineering of antibodies, bispecific antibody engineering and adapting to create an antigen receptor that is chimeric.