Interleukin-1 alpha Antibodies

Interleukin-1 alpha (IL1A)

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor action. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

.

Gene Information

Human
Gene Name:	IL1A
Uniprot:	P01583
Entrez:	3552

Family

Belongs to:
IL-1 family

Alternative Names

BAF; Hematopoietin-1; IL1 alpha; IL-1 alpha; IL1; IL1A; IL-1A; IL1-ALPHA; IL1F1; IL-1F1; IL1F1hematopoietin-1; interleukin 1, alpha; interleukin-1 alpha; LAF; LEM; preinterleukin 1 alpha; pro-interleukin-1-alpha

Molecular Weight

Mass (kDA):
30.607 kDA

Genomic Context

Human
Location:	2q14.1
Sequence:	2; NC_000002.12 (112773925..112784493, complement)

Subcellular Localizations

Secreted. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

Diseases

• Inflammation
• Malignant Neoplasms
• Inflammatory Response
• Alzheimer's Disease
• Variable Number Tandem Repeat
• Neoplasms
• Dysequilibrium Syndrome
• Cholangiocarcinoma
• Periodontitis
• Arthritis
• Carcinogenesis
• Spondylitis
• Degenerative Polyarthritis

• Carcinoma
• Tissue Adhesions
• Asthma
• Ankylosing Spondylitis
• Sclerosis
• Malignant Neoplasm Of Breast
• Mammary Neoplasms

Interacting Proteins

• CASP1
• HAX1
• IL1R2
• KPNA6
• MEOX2

Pathways

• Pathogenesis
• Inflammatory Response
• Immune Response
• Secretion
• Parturition
• Wound Healing
• Localization
• Cytokine Production
• Cell Death
• Angiogenesis
• Cell Adhesion
• Cell Activation
• Cell Proliferation

• Dna Repair
• Ovulation
• Tissue Homeostasis
• Cell Cycle
• Innate Immune Response
• Cell Migration
• Regulation Of Programmed Cell Death

PTMs

• Cleavage
• Phosphorylation
• Biotinylation

• Reduction
• Acetylation
• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL1A

Boster Bio Anti-IL1A Monoclonal Antibody Picoband

If you've ever wondered what Boster Bio's Anti-IL1A Monoclonal Antibody Picoband, you're not alone. Interleukin-1 beta is a cytokine protein that can be detected with this antibody. Here are some of the best uses for this cytokine protein. Read on to find out more! Listed below are the top three uses for this Cytokine protein:

Boster Bio Anti-IL1A Monoclonal Antibody Pioband

Boster Bio was founded in 1993, and is a leader in the creation of research antibodies as well as picogram sensitive ELISA kits. They can be used in biomarker detection in the field of developmental biology, cancer research, neurosciences, inflammation, and other areas. Boster Bio antibodies have been tested against a variety of 250 tissue and cell lines and are highly specific. These antibodies are highly specific and have high affinity and sensitivity. They can be used for flow cytometry, immunofluorescence and ELISA tests.

The product is recombinant and can be stored at -20°C for one year or at 4degC over a month. This monoclonal antibody is created using recombinant Rat IL1A proteins and is highly compatible with rabbit and mouse IL1RA. The Boster Bio Anti-IL1RA/IL1rn is high-affinity antigen derived from rat and mouse IL1RA proteins.

The IL1A Marker, which is a cell cytokine protein, is a Cytokine.

IL1A marker is a protein present in the human cytoplasm. It has a dual purpose in the body, acting both as an immune-regulatory as well as a proinflammatory cytokine. When IL-1a is present in the cytosol it interacts with regulatory proteins and transcriptional factors. When IL-1a expression is found in the nucleus, it is unavailable to trigger inflammation.

Complex genetic inheritance is associated with inflammatory diseases. There is a connection between an increased likelihood of developing these illnesses and a genetic polymorphism the IL-1A or IL1A. The hypothesis is that these alleles would alter the physiological functions of the IL-1. There are conflicting reports about this genetic connection. Many studies that examine the genetic predisposition of disease make use of single-nucleotide polymorphisms (SNPs) to study IL-1/R group alleles that are associated with risk of developing disease.

Interleukin-1a is produced by a wide range of cells, including macrophages, neutrophils and epithelial cells. It is secreted by activated macrophages and stimulates the production of tumor necrosis factor alpha. It is also produced by various types of cells such as endothelial cells and myeloid cells. In addition to endothelial cell, lymph node cells, and placental cells from mothers also produce IL-1a.

It is a precursor protein without the signal peptide segment. The precursor is processed by proteases to form its "mature" molecule. Calpain is a calcium-activated cysteine proteinase is the enzyme responsible for conversion of the precursor into a mature molecule. Proteases like Calpain break down the precursor molecules.

When a cell releases a necrotic cells, IL-1a is made. The pro-IL-1a precursor triggers the IL-1R1 on resident macrophages found in necrotic tissues. This triggers the production of IL-1b. The inflammation process continues until the cell dies. Inflammation is triggered by IL-1A after the precursor is released by necrotic cells.

The inflammation that results from sepsis is extremely complicated and dynamic. It involves the excessive production of proinflammatory cytokines as well as suppressive immune responses. A lack of balance in the immune response could cause tissue damage and organ failure. Important regulators of the pleiotropic immune system, cytokines may stimulate tissue-damaging inflammation, or inhibit the response to infections.

It can be used for interleukin-1 beta detection

The Boster Bio I1A marker can detect interleukin-1 beta. It is developed to detect interleukin-1 beta and its metabolites. This antibody is approved for research. It can be stored at -20°C for a year, or at 4°C for one month. This antibody contains 5 mg BSA, 0.05 mg Thimerosal and 1 milliliter. It reacts with human IL-1 beta (249-269aa). To avoid false positive results, it is advised to purchase a blocking peptide with an exact length of the immunogen.

The study also showed that the levels of IL-1a are correlated with surgical response. It was also suggested that IL-1a might be a biomarker for the presence of disease. This study assessed the levels of IL-1a in the blood of patients with Asymptomatic AAA. The size and shape of the AAA were not affected by the detection of the IL-1a.

The proteinaceous signaling compound IL-18Rb is called IL-18B. It is extremely active with pg/mL levels, and can be found in inflammatory conditions , such as cancer and HIV. This cytokine controls a myriad of cellular functions and is a crucial mediator of the immune response. It is involved in several pathophysiological processes , and is utilized in clinical trials.

The Boster Bio IL1A marker which can be used to detect the IL-1 receptor, could also be employed. This cytokine can be produced by macrophages that are activated. The caspase 1 enzyme further converts it into active form. The IL-1R1 cytokine plays a crucial role in the immune system.

In a recent study, researchers investigated the relationship between IL-1a levels and the maximum AP diameter of patients with infrarenal AAA. The majority of patients had serum levels of IL-1a (62.4%). This suggests that the biomarker IL-1a could be a useful one to use in the treatment of AAA. These findings are still in the early stages and should be further tested.

The precursor to IL-1A is released during an inflammation that is sterile and ready to perform its function within hours of tissue ischemia. Its inhibition is effective in reducing the development of atherosclerosis. It has been proven that IL-1a inhibition can reduce symptoms of acute MI and ischemic stroke. Two pilot studies showed that there was a reduction in acute inflammation and a improved overall performance after three months.

It can be used to detect beta cells of interleukin-1.

Boster Bio IL1A is a highly sensitive test for interleukin-1 beta. It measures intracellular levels of this proinflammatory cytokine within human cells. The inflammasome enzyme processes pro-IL-1 beta to its active form of 17 kDa. IL-1 beta is produced by inflammation cells when they are exposed to pathogens or stress. Inflammasomes respond by cleaving pro-IL-1 beta, which is a precursor to caspase-1. The precursor is inactive within human cells and does not contain the signal peptide that is found in the traditional Golgi/ER pathways.

You can purchase the Boster Bio IL1A monoclonal antibody. It is approved for use in immunohistochemistry to detect interleukin-1 beta cells. The antibody reacts with rat and mouse cells. The Boster product has 5 mg of BSA and 0.05 mg of Thimrosal.

The enzyme can detect the expression of IL-1a and IL-1b in human cells. The IL-1a protein is found in a variety of tissues, including the lymphoid organs, as well as the gastrointestinal tract. It is also involved in the regulation of B-cell activity and the activity of fibroblast growth factor. It has been associated with cancer metastasis and development. It is a cytokine in the innate immune system and is a major factor in host-defence responses.

The bioactive form of IL-1b can be found in shed microvesicle-free excosomes and secreted from plasma membrane. The plasma half-life is extremely short and it is released by several extracellular mechanisms. Because IL-1b is an incredibly complex protein it is difficult to understand the mechanism of its release. is difficult.

In addition to pro-IL-1a forms and the enzyme-linked immunosorbent test (ELISA) method is another method to measure the level of IL-1a. It can detect pro-IL-1a levels in cells by sandwich ELISA. It was also found that pro-IL-1a is present in plasma membrane. This is a crucial cytokine because it can trigger other proinflammatory chemical substances in the targeted cells.

IL-1b is packaged in exosomes. These are small vesicles, usually between 50 and 80 nanometers, secreted by cells. Anna Rubartelli, a BFA researcher, studied the production of by IL-1b throughout the 1990s. The inhibition of TNFa and IL-1a with BFA blocked their release and enhanced the secretion of IL-1b.