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- Table of Contents
Facts about Interleukin-17 receptor E.
Specific functional receptor for IL17C, signaling through the NF-kappa-B and MAPK pathways.
Requires TRAF3IP2 /ACT1 for signaling.Crucial regulator in innate immunity to bacterial pathogens, such as Citrobacter rodentium. Isoform 4 and isoform 5 could be cytoplasmic inactive or dominant active forms.
Mouse | |
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Gene Name: | Il17re |
Uniprot: | Q8BH06 |
Entrez: | 57890 |
Belongs to: |
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No superfamily |
IL-17 RE; IL-17 receptor E; IL17RE; IL-17RE; Il25r; interleukin 17 receptor E
Mass (kDA):
70.833 kDA
Mouse | |
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Location: | 6|6 E3 |
Sequence: | 6; |
Predominantly expressed in mucosal tissues, including trachea, lung, kidney and stomach. Highly expressed in colon epithelial cells. Also expressed in testis. Low expression, if any, in heart, liver, spleen, or brain. Among CD4 T-helper cells, expressed at high levels in Th17 cells.
PMID: 16310341 by Li T.-S., et al. Identification and functional characterization of a novel interleukin 17 receptor: a possible mitogenic activation through ras/mitogen- activated protein kinase signaling pathway.
PMID: 21982598 by Chang S.H., et al. Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E.