Interleukin-17 receptor E (Il17re)

Specific functional receptor for IL17C, signaling through the NF-kappa-B and MAPK pathways.

Requires TRAF3IP2 /ACT1 for signaling.

Crucial regulator in innate immunity to bacterial pathogens, such as Citrobacter rodentium. Isoform 4 and isoform 5 could be cytoplasmic inactive or dominant active forms.