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- Table of Contents
2 Citations 9 Q&As
14 Citations 7 Q&As
Facts about Interleukin-17F.
Ligand for IL17RA and IL17RC (PubMed:17911633).
The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971).Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732).
Human | |
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Gene Name: | IL17F |
Uniprot: | Q96PD4 |
Entrez: | 112744 |
Belongs to: |
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IL-17 family |
Cytokine ML-1; IL17F; IL-17F; IL-17Finterleukin-17F; IL24; IL-24; interleukin 17F; Interleukin-24; ML-1; ML1interleukin-24
Mass (kDA):
18.045 kDA
Human | |
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Location: | 6p12.2 |
Sequence: | 6; NC_000006.12 (52236681..52245689, complement) |
Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.
Secreted.
PMID: 11591732 by Starnes T., et al. IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production.
PMID: 11591768 by Kawaguchi M., et al. Identification of a novel cytokine, ML-1, and its expression in subjects with asthma.
*More publications can be found for each product on its corresponding product page