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- Table of Contents
3 Citations 8 Q&As
2 Citations
Facts about Cation-independent mannose-6-phosphate receptor.
This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.
Human | |
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Gene Name: | IGF2R |
Uniprot: | P11717 |
Entrez: | 3482 |
Belongs to: |
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MRL1/IGF2R family |
300 kDa mannose 6-phosphate receptor; cation-independent mannose-6 phosphate receptor; cation-independent mannose-6-phosphate receptor; CD222 antigen; CD222; CI Man-6-P receptor; CIMPR; CI-MPR; IGF2R; IGF-II R; IGF-II receptor; IGFIIR; IGF-IIR; insulin-like growth factor 2 receptorM6P/IGF2R; Insulin-like growth factor II receptor; M6P/IGF2 receptor; M6PR; M6P-R; MPR 300; MPR1; MPRI; MPRIM6PR
Mass (kDA):
274.375 kDA
Human | |
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Location: | 6q25.3 |
Sequence: | 6; NC_000006.12 (159969082..160111504) |
Lysosome membrane; Single-pass type I membrane protein. Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.
PMID: 2957598 by Morgan D.O., et al. Insulin-like growth factor II receptor as a multifunctional binding protein.
PMID: 2963003 by Oshima A., et al. The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells.
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