Itm2c Antibodies

AND Itm2c ELISA kits, Itm2c Proteins

Many biological assays use antibodies to detect Itm2c, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Itm2c in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Itm2c antibodies...

We validate the specificity of these antibodies to Itm2c by testing them on tissues known to express Itm2c positively and negatively. Browse below to find the Itm2c antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Itm2c Infographic by Boster Bio

All Itm2c Products

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Specificity

Applications

Price

ITM2C (NM_030926) Human Over-expression Lysate

Human

$628
Cat # LS081618
100 µg

Anti-ITM2C Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A08857-1
100 μg/vial

Itm2c Overview

Facts about Integral membrane protein 2C.

Integral membrane protein 2C (Itm2c)

Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase.

Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF- induced cell death and neuronal differentiation.

Gene Information

Mouse
Gene Name:	Itm2c
Uniprot:	Q91VK4
Entrez:	64294

Family

Belongs to:

ITM2 family

Alternative Names

BRI3; BRI3E25C; BRICD2C; BRICHOS domain containing 2C; Cerebral protein 14; E25; hRPC.1050_D_4; integral membrane protein 2C; integral membrane protein 3; ITM2C; ITM3; Transmembrane protein BRI3

Molecular Weight

Mass (kDA):
30.482 kDA

Genomic Context


Mouse

Location:	1\|1 C5
Sequence:	1;

Diseases

Stomach Neoplasms
Neoplasms
Alzheimer's Disease
Peritoneal Carcinomatosis
Learning Disorders
Infarction
Neurodegenerative Disorders
Dementia
Myocardial Infarction
Malignant Neoplasms
Hemorrhage
Cerebrovascular Accident
Nervousness

Memory Impairment
Ischemic Stroke
Proteostasis Deficiencies
Nerve Degeneration
Brain Hemorrhage
Intracranial Hemorrhages
Cardiac Fibrillation

Pathways

Endochondral Ossification
System Development
Nervous System Development
Cell Differentiation
Tube Formation
Proteolysis
Immune Response

Cell Growth
Ossification

PTMs

Cleavage on pair of basic residues
Disulfide bond

Glycoprotein
Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Itm2c

References

PMID: 10679242 by Inoue S., et al. Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains.

PMID: 11290423 by Vidal R., et al. Sequence, genomic structure and tissue expression of human BRI3, a member of the BRI gene family.