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ITM2B Antibodies
AND ITM2B ELISA kits, ITM2B Proteins
Many biological assays use antibodies to detect ITM2B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ITM2B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ITM2B antibodies...
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ITM2B Infographic by Boster Bio
All ITM2B Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$523
Cat # M03157
100 µl
Cat # M03157
100 µl
ITM2B Overview
Facts about Integral membrane protein 2B.
Integral membrane protein 2B (ITM2B)
Plays a regulatory function in the processing of this amyloid-beta A4 precursor protein (APP) and functions as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth.
Functions as a protease inhibitor by blocking access of secretases to APP cleavage websites. .
Gene Information
| Human | |
|---|---|
| Gene Name: | ITM2B |
| Uniprot: | Q9Y287 |
| Entrez: | 9445 |
Family
| Belongs to: |
|---|
| ITM2 family |
Alternative Names
ABRI; ABri/ADan amyloid peptide; BRI; BRI2; BRICD2B; BRICHOS domain containing 2B; BRIFBD; E25B; E3-16; FBD; integral membrane protein 2B; ITM2B; Protein E25B; Transmembrane protein BRI
Molecular Weight
Mass (kDA):
30.338 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q14.2 |
| Sequence: | 13; NC_000013.11 (48233206..48270357) |
Tissue Specificity
Ubiquitous. Expressed in brain.
Subcellular Localizations
[Integral membrane protein 2B]: Golgi apparatus membrane; Single-pass type II membrane protein. Immature BRI2 (imBRI2) is cleaved by furin in the Golgi into mBRI2 and a Bri23 peptide. mBRI2 is transported to the plasma membrane and Bri23 peptide is secreted.; [BRI2, membrane form]: Cell membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein. Mature BRI2 (mBRI2) needs to be transported from the endoplasmic reticulum compartment to the cell membrane in order to be able to inhibit APP processing.; [Bri23 peptide]: Secreted. Detected in the cerebral
Diseases
- Dementia
- Alzheimer's Disease
- Heredopathia Ophthalmootoencephalica
- Plaque, Amyloid
- Neurodegenerative Disorders
- Neurofibrillary Tangles
- Nerve Degeneration
- Cerebral Amyloid Angiopathy
- Vascular Diseases
- Senile Cerebral Amyloid Angiopathy
- Cerebellar Ataxia
- Amyloid Deposition
- Cataract
Interacting Proteins
- BACE1
- CCDC155
- NAALADL2
- SYNE4
Pathways
- Pathogenesis
- Proteolysis
- Secretion
- Cell Death
- Secretory Pathway
- Inflammatory Response
- Cell Cycle
- Cognition
- Protein Processing
- Transport
- Programmed Cell Death
- Cellular Homeostasis
- Aging
PTMs
- Cleavage
- Phosphorylation
- Biotinylation
Research Areas
- Neuroscience
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITM2B
bosterbio.com/bosterbio-gene-info-cards/ITM2B
References
PMID: 10391242 by Vidal R., et al. A stop-codon mutation in the BRI gene associated with familial British dementia.
PMID: 10781099 by Vidal R., et al. A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred.