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- Table of Contents
Facts about Glutathione S-transferase omega-1.
Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.
Human | |
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Gene Name: | GSTO1 |
Uniprot: | P78417 |
Entrez: | 9446 |
Belongs to: |
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GST superfamily |
DKFZp686H13163; EC 2.5.1.18; glutathione S-transferase omega 1; glutathione S-transferase omega 1-1; glutathione S-transferase omega-1; glutathione-S-transferase like; GSTO-1; GSTTLp28; P28
Mass (kDA):
27.566 kDA
Human | |
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Location: | 10q25.1 |
Sequence: | 10; NC_000010.11 (104254194..104267464) |
Ubiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon, blood leukocyte and heart. Lowest expression in brain, placenta and lung.
Cytoplasm, cytosol.
PMID: 10783391 by Board P.G., et al. Identification, characterization, and crystal structure of the Omega class glutathione transferases.
PMID: 12928150 by Yu L., et al. Genetic variation in genes associated with arsenic metabolism: glutathione S-transferase omega 1-1 and purine nucleoside phosphorylase polymorphisms in European and indigenous Americans.