ITK Antibodies

Tyrosine-protein kinase ITK/TSK (ITK)

Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells.

When antigen presenting cells (APC) trigger T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK into the cell membrane, in the vicinity of the aroused TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and complete activation.

Gene Information

Human
Gene Name:	ITK
Uniprot:	Q08881
Entrez:	3702

Family

Belongs to:
protein kinase superfamily

Alternative Names

EC 2.7.10; EC 2.7.10.2; EMT; EMTMGC126257; homolog of mouse T-cell itk/tsk; IL2-inducible T-cell kinase; ITK; Kinase EMT; LYK; LYKMGC126258; PSCTK2; T-cell-specific kinase; Tcsk; tyrosine-protein kinase ITK/TSK; Tyrosine-protein kinase Lyk

Molecular Weight

Mass (kDA):
71.831 kDA

Genomic Context

Human
Location:	5q33.3
Sequence:	5; NC_000005.10 (157180840..157255185)

Tissue Specificity

T-cell lines and natural killer cell lines.

Subcellular Localizations

Cytoplasm. Nucleus. Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation.

Diseases

• Inflammation
• Asthma
• Agammaglobulinemia
• Tissue Adhesions
• Immunologic Deficiency Syndromes
• Allergic Asthma
• X-linked Agammaglobulinemia
• Malignant Neoplasms
• Lymphoma
• Neoplasms
• Leukemia
• Autoimmune Reaction
• T-cell Lymphoma

• Autoimmune Diseases
• Peripheral T-cell Lymphoma
• Bronchial Hyperreactivity
• Virus Diseases
• Intestinal Diseases
• Chromosomal Translocation
• Leukemia, T-cell

Interacting Proteins

• ERBB2
• FASLG
• HSP90AB1
• LCP2

Pathways

• Cell Activation
• T Cell Activation
• Secretion
• Cell Development
• Cytokine Production
• Localization
• Segmentation
• Cell Proliferation
• Immune Response
• Cytokine Secretion
• Cell Differentiation
• Pathogenesis
• Cell Adhesion

• Cell Migration
• Translation
• Cell Death
• T Cell Migration
• T Cell Proliferation
• Cell Growth
• Cell Maturation

PTMs

• Phosphorylation
• Palmitoylation
• Cleavage

• Acetylation
• Dephosphorylation
• Myristoylation

Research Areas

• Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITK

Boster Bio - Best Uses Of The ITK Marker

This article will offer some tips for using a boster bio ELISA kits if you're scientist. This article will teach you how to use Picoband ELISA to identify target cells and identify their presence in samples. This tool allows you to experiment with a wide range of sample types, even those that are difficult to identify using ELISA kits.

Picokine ELISA platform

Picokine(tm) Picokine(tm), an ELISA platform, was designed to detect antigens of interest. The technology enhances the binding capacity of capture antibodies, which results in less background and a single-digit picogram level sensitivity. It has been rigorously tested and validated for several samples. Picokine(tm), an ELISA platform, is available through tebu bio and compatible with a range of samples.

ELISA tests use specific antibodies to identify specific analytes. The antibodies can wash away non-specific bound substances, making this a powerful instrument for analyzing the specific analyte within a simple preparation. The ELISA platform can be purchased in three different formats: sandwich (96-well), 384-well, or 384-well. These formats are standard and allow you to capture both the protein of interest as well as the antigen of the target.

Sandwich ELISA platforms employ a capture and detect antibody that detects distinct epitopes. This is ideal for sandwich ELISA. Both the antibodies for detection and capture are typically distinct species. If the detection and capture antibodies recognize different epitopes, both sensitivity and dynamic range will be diminished. The most effective option is to use matched pairs. option for sensitivity tests.

Picokine(tm) is an ELISA platform with high sensitivity, enhances sensitivities to the picogram level. The Picokine ELISA platform is validated in a variety of samples. Images are available upon request. Picoband also includes Supervision Polymer, a polymer-based second antigen that can be used to cut down time and costs in IHC. These products are supported by Sanbio's technical assistance and Sanbio's commitment to supplying high-quality products.

The system is easy to use and can be tailored to meet specific research needs. This system can detect specific proteins in complex mixtures. It works by immobilizing a sample on a plate using an antigen or antibody. The antigen and the antibody are bound together and the result is determined by the presence or absence of the substrate. It is possible to identify the presence of several antigen molecules by analyzing the amount of protein in the sample.

Another advantage of the Picokine ELISA platform is its ability to detect multiple biomarkers simultaneously at the same at the same time. The ELISA platform can detect many biomarkers like cancer cells and tumor markers. As a result, Picokine ELISA is a highly accurate method to determine the levels of these biomarkers present in samples. But it is important to know the concentration of the biomarker prior to using the Picokine ELISA platform.