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- Table of Contents
Facts about Inosine triphosphate pyrophosphatase.
Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. .
Human | |
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Gene Name: | ITPA |
Uniprot: | Q9BY32 |
Entrez: | 3704 |
Belongs to: |
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HAM1 NTPase family |
C20orf37; dJ794I6.3; EC 3.6.1; EC 3.6.1.19; HLC14-06-P; inosine triphosphatase (nucleoside triphosphate pyrophosphatase); Inosine triphosphatase; inosine triphosphatase-A; inosine triphosphate pyrophosphatase; inosine triphosphate pyrophosphohydrolase; ITPase; My049 protein; nucleoside triphosphate diphosphatase; Putative oncogene protein hlc14-06-p
Mass (kDA):
21.446 kDA
Human | |
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Location: | 20p13 |
Sequence: | 20; NC_000020.11 (3208676..3227449) |
Ubiquitous. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland.
Cytoplasm.
PMID: 11278832 by Lin S., et al. Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the ITPA gene.
PMID: 17090528 by Burgis N.E., et al. Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase.