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Integrin beta-4 Antibodies
AND ITGB4 ELISA kits, Integrin beta-4 Proteins
Many biological assays use antibodies to detect Integrin beta-4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Integrin beta-4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Integrin beta-4 antibodies...
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ITGB4 Infographic by Boster Bio
All ITGB4 Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # PB9007
100 μg/vial
Cat # PB9007
100 μg/vial
Human, Mouse, Rat
ELISA
$480
Cat # EKC1305
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1305
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2303
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2303
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A01015Y1510
100ul
Cat # A01015Y1510
100ul
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A01015-2
100 μg/vial
Cat # A01015-2
100 μg/vial
Human
Flow Cytometry, IF, ICC, WB
$370
Cat # M01015-2
100 μg/vial
Cat # M01015-2
100 μg/vial
ITGB4 Overview
Facts about Integrin beta-4.
Integrin beta-4 (ITGB4)
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells.
Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778).
Gene Information
| Human | |
|---|---|
| Gene Name: | ITGB4 |
| Uniprot: | P16144 |
| Entrez: | 3691 |
Family
| Belongs to: |
|---|
| integrin beta chain family |
Alternative Names
CD104 antigen; CD104; GP150; Integrin beta 4; integrin beta-4 subunit; integrin beta-4; integrin, beta 4; ITGB4
Molecular Weight
Mass (kDA):
202.167 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q25.1 |
| Sequence: | 17; NC_000017.11 (75721339..75757819) |
Tissue Specificity
Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Colocalizes with DST at the leading edge of migrating keratinocytes.
Diseases
- Epidermolysis Bullosa
- Atresia
- Malignant Neoplasms
- Junctional Epidermolysis Bullosa
- Bulla
- Tissue Adhesions
- Epidermolysis Bullosa Junctionalis With Pyloric Atresia
- Neoplasms
- Neoplasm Metastasis
- Carcinoma
- Cell Invasion
Interacting Proteins
- ARRDC3
- ITGA6
- PLEC
- PTK2
- S1PR2
- S1PR3
Pathways
- Cell Adhesion
- Cell Proliferation
- Cell Migration
- Immune Response
- Translation
- Pathogenesis
- Cell Cycle
- Invasive Growth
- Cell Growth
- Angiogenesis
- Transport
- Cell Activation
- Neutrophil Extravasation
PTMs
- Disulfide bond
- Glycoprotein
Research Areas
- Adaptive Immunity
- Immunology
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITGB4
bosterbio.com/bosterbio-gene-info-cards/ITGB4
References
PMID: 2311577 by Suzuki S., et al. Amino acid sequence of a novel integrin beta 4 subunit and primary expression of the mRNA in epithelial cells.
PMID: 2311578 by Hogervorst F., et al. Cloning and sequence analysis of beta-4 cDNA: an integrin subunit that contains a unique 118 kd cytoplasmic domain.