Integrin alpha-E Antibodies

Integrin alpha-E (ITGAE)

Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.

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Gene Information

Human
Gene Name:	ITGAE
Uniprot:	P38570
Entrez:	3682

Family

Belongs to:
integrin alpha chain family

Alternative Names

antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide; CD103 antigen; CD103; HML-1 antigen; HUMINAE; Integrin alpha E; integrin alpha-E; Integrin alpha-IEL; integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alphapolypeptide); ITGAE; MGC141996; Mucosal lymphocyte 1 antigen

Molecular Weight

Mass (kDA):
130.159 kDA

Genomic Context

Human
Location:	17p13.2
Sequence:	17; NC_000017.11 (3714628..3803766, complement)

Tissue Specificity

Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

• Tissue Adhesions
• Neoplasms
• Inflammation
• Neoplasm Metastasis
• Brain Ischemia
• Coronary Heart Disease
• Melanoma
• Tumor Progression
• Inflammatory Bowel Diseases
• Endometrial Polyp
• Neoplasm Invasiveness
• Intestinal Diseases
• Cardiovascular Diseases

• Fibrosis
• Sarcoidosis, Pulmonary
• Tumor Angiogenesis
• Mucocutaneous Lymph Node Syndrome
• Malignant Neoplasms
• Cerebrovascular Accident
• Sarcoidosis

Pathways

• Cell Adhesion
• Actin Cytoskeleton Organization
• Response To Stress
• Cell Proliferation
• Immune Response
• Dna Methylation
• Cell-matrix Adhesion
• Methylation
• Cytoskeleton Organization
• T Cell Differentiation

• Cell Differentiation
• Cell Growth
• Angiogenesis
• Autophagy

PTMs

• Cleavage on pair of basic residues

• Disulfide bond

• Glycoprotein

Research Areas

• Innate Immunity

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITGAE

Best Uses Of The ITGAE Marker

The ITGAE gene is one of the most crucial markers in the study of cancer since it is involved in the development of the immune system. Apart from coding for the ITGAE gene it also codes for the ITGAE protein is also known as FLT3L. The ITGAE marker is also used to identify cells with FLT3L expression. It's still a very popular marker but it is often under-utilized.

GM-CSF

The ITGAE Marker is a transduction protein, which is located in the endoplasmic reticulum. There are a variety of ways to alter and study the genetic material that cells carry. Boster offers comprehensive technical sources, including blogs and information about diseases, as in digital tools that are accessible via the internet. Boster also provides high-quality lysis buffers that guarantee good results by reducing the intensity of cross-linking.

FLT3L

The ITGAE Marker is a sign of gastrointestinal tract cancer in humans. The majority of intestinal cells have the ITGAE gene. Because this gene is expressed on cells throughout the body, it plays many important functions. The ITGAE gene is involved in numerous processes in the body, including digestion, reproduction, and immunity. If you're looking to find an innovative way to diagnose a problem, this marker can help in determining the cause of the problem.