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Integrin alpha-D Antibodies
AND ITGAD ELISA kits, Integrin alpha-D Proteins
Many biological assays use antibodies to detect Integrin alpha-D, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Integrin alpha-D in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Integrin alpha-D antibodies...
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ITGAD Infographic by Boster Bio
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ITGAD Overview
Facts about Integrin alpha-D.
Integrin alpha-D (ITGAD)
Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.
May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood- borne pathogens, particulate matter, and senescent erythrocytes in the blood..
Gene Information
| Human | |
|---|---|
| Gene Name: | ITGAD |
| Uniprot: | Q13349 |
| Entrez: | 3681 |
Family
| Belongs to: |
|---|
| integrin alpha chain family |
Alternative Names
ADB2; CD11 antigen-like family member D; CD11d; FLJ39841; Integrin alpha D; integrin alpha-D; integrin, alpha D; Leukointegrin Alpha D
Molecular Weight
Mass (kDA):
126.758 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p11.2 |
| Sequence: | 16; NC_000016.10 (31393223..31426513) |
Tissue Specificity
Expressed moderately on myelomonocytic cell lines and subsets of peripheral blood leukocytes and strongly on tissue-specialized cells, including macrophages foam cells within atherosclerotic plaques, and on splenic red pulp macrophages.
Subcellular Localizations
Membrane; Single-pass type I membrane protein.
Diseases
- Tissue Adhesions
- Inflammation
- Spinal Cord Injuries
- Myelitis
- Extravasation
- Inflammatory Response
- Patient Dependence On
- Lung Injury
- Fatty Streaks
- Central Nervous System Inflammation
- Inflammatory Bowel Diseases
- Teratocarcinoma
Pathways
- Cell Adhesion
- Localization
- Inflammatory Response
- Cell Activation
- Cell Proliferation
- Cell Development
- Complement Activation
- Platelet Activation
- Myeloid Cell Differentiation
- Cytokine Production
- Foam Cell Differentiation
PTMs
- Nitration
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITGAD
bosterbio.com/bosterbio-gene-info-cards/ITGAD
References
PMID: 8777714 by Van der Vieren M., et al. A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM- 3.
PMID: 10722744 by Noti J.D., et al. Structural and functional characterization of the leukocyte integrin gene CD11d. Essential role of Sp1 and Sp3.