Integrin alpha-8 Antibodies

AND ITGA8 ELISA kits, Integrin alpha-8 Proteins

Many biological assays use antibodies to detect Integrin alpha-8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Integrin alpha-8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Integrin alpha-8 antibodies...

We validate the specificity of these antibodies to Integrin alpha-8 by testing them on tissues known to express ITGA8 positively and negatively. Browse below to find the ITGA8 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ITGA8 Infographic by Boster Bio

All ITGA8 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Integrin alpha-8 ITGA8 Antibody

Human, Mouse, Rat

$405
Cat # A06636
100ul

Anti-ITGA8 Antibody (C-term)

Human

IHC-P, WB

$299
Cat # A06636-1
80 µl

ITGA8 (NM_003638) Human Over-expression Lysate

Human

$960
Cat # LS008516
100 µg

Anti-ITGA8 Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A06636-2
100 µg/vial

ITGA8 Overview

Facts about Integrin alpha-8.

ITGA8 3D structure. Source: alphafold

Integrin alpha-8 (ITGA8)

Integrin alpha-8/beta-1 works from the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells to epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands such as TNC, FN1, SPP1 TGFB1, TGFB3 and VTN.

NPNT is likely its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and modulates neurite outgrowth of sensory and motor neurons.

Gene Information

Human
Gene Name:	ITGA8
Uniprot:	P53708
Entrez:	8516

Family

Belongs to:

integrin alpha chain family

Alternative Names

Integrin alpha 8; integrin alpha-8; integrin, alpha 8; ITGA8

Molecular Weight

Mass (kDA):
117.474 kDA

Genomic Context


Human

Location:	10p13
Sequence:	10; NC_000010.11 (15513949..15720335, complement)

Tissue Specificity

Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level).

Subcellular Localizations

Membrane; Single-pass type I membrane protein. Cell membrane.

Diseases

Tissue Adhesions
Hypertensive Disease
Cholangiocarcinoma
Essential Hypertension
Cardiac Hypertrophy
Labyrinthine Disorder
Endometrial Polyp
Sensation Disorders
Lung Diseases
Parkinson Disease
Injury To Kidney
Fibrosis

Cardiovascular Diseases
Malignant Neoplasms
Flushing
Neoplasms
Nervousness
Asthma

Pathways

Cell Adhesion
Tissue Remodeling
Lung Development
Methylation
Cell Migration
Gastrulation
Dna Methylation
Localization
Demethylation
Embryo Development
Blastocyst Formation

Reverse Transcription
Phagocytosis
Synapse Assembly
Pathogenesis
Kidney Development

PTMs

Methylation

Demethylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITGA8

References

PMID: 7768999 by Schnapp L.M., et al. Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells.

PMID: 10504498 by Hartner A., et al. Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis.