Integrin alpha-8 Antibodies

Integrin alpha-8 (ITGA8)

Integrin alpha-8/beta-1 works from the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells to epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands such as TNC, FN1, SPP1 TGFB1, TGFB3 and VTN.

NPNT is likely its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and modulates neurite outgrowth of sensory and motor neurons.

Gene Information

Human
Gene Name:	ITGA8
Uniprot:	P53708
Entrez:	8516

Family

Belongs to:
integrin alpha chain family

Alternative Names

Integrin alpha 8; integrin alpha-8; integrin, alpha 8; ITGA8

Molecular Weight

Mass (kDA):
117.474 kDA

Genomic Context

Human
Location:	10p13
Sequence:	10; NC_000010.11 (15513949..15720335, complement)

Tissue Specificity

Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level).

Subcellular Localizations

Membrane; Single-pass type I membrane protein. Cell membrane.

Diseases

• Tissue Adhesions
• Hypertensive Disease
• Cholangiocarcinoma
• Essential Hypertension
• Cardiac Hypertrophy
• Labyrinthine Disorder
• Endometrial Polyp
• Sensation Disorders
• Lung Diseases
• Parkinson Disease
• Injury To Kidney
• Fibrosis

• Cardiovascular Diseases
• Malignant Neoplasms
• Flushing
• Neoplasms
• Nervousness
• Asthma

Pathways

• Cell Adhesion
• Tissue Remodeling
• Lung Development
• Methylation
• Cell Migration
• Gastrulation
• Dna Methylation
• Localization
• Demethylation
• Embryo Development
• Blastocyst Formation

• Reverse Transcription
• Phagocytosis
• Synapse Assembly
• Pathogenesis
• Kidney Development

PTMs

• Methylation

• Demethylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITGA8

Boster Bio - Best Uses Of The ITGA8 Marker

You've heard of Immunofluorescence, but don't know where to begin. Boster Bio’s ITGA8 Marker is versatile and can be used to enhance your research. Here are some of its most popular uses. It can also be used to confirm the presence of a protein in a sample.

Boster Bio: Anti-Integrin alpha 3/ITGA3 Antibody Picoband

Boster Bio Anti-Integrinalpha /3-ITGA3 Antibody belongs to the Picoband(tm). It reacts with Human. It is a monoclonal, purified antibody by peptide affinity or protein A columns. It is created by immunizing rabbits (ranging in amino acid sequences from 165 up to 199) with a synthetic propeptide. It has been tested for compatibility with the human immune system by flow cytometry, IHC, WB, and ELISA.

This monoclonal anti-ITGA3 antibody has been validated on mouse tissue and is highly recommended for immunofluorescence labeling, immunohistochemistry, western blotting, and IHC. The immunoglobulins include integrins which are complex receptors of fibronectin laminin collagen, epiligrin, and fibronectin. The molecule is made up of alpha and beta subunits. The alpha unit is made up of a single transmembrane. It may also serve as a docking location for the seprase.

Boster scientists can submit results for species, special samples, and applications using this product. In addition to this, they may also receive product credits. This is available to all scientists worldwide. You can find the boster Bio website if you want to learn more about this antigen. The full PDF of the study report is available for download.

Boster Bio: Immunofluorescence

ITGA8 is a highly-specific molecule that is expressed only on mesangial glomerulus cells. Single-cell sequencing has confirmed that ITGA8 is highly specific. This indicates that ITGA8 has important regulatory capabilities. Itga8 is a mesangial cell adhesion inhibitor, which suppresses migration and confers mechanical stability on the glomerulus. ITGA8 also improves mechanical stability of the glomerular capillary tip in a DOCA salt hypertension model.

Immunofluorescence

ITGA8 is a protein which binds to mesangial cells within the glomerulus. Single cell sequencing confirmed its uniqueness. It also plays important regulatory roles, including adhesion and suppression migration. ITGA8 also adds mechanical stability and stability to glomerulus in DOCA-salt hypertension studies.

Mice with a genetic mutation of itga8 in glomerulonephritis will develop delayed glomerulonephritis. However, itga8 deficiency does not promote fibrosis either in vitro nor in vivo. Itga8 is also required for the reorganization and maintenance of the cytoskeleton. It can also impair cell contractility.