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- Table of Contents
Facts about Inositol polyphosphate-4-phosphatase type I A.
Human | |
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Gene Name: | INPP4A |
Uniprot: | Q96PE3 |
Entrez: | 3631 |
Belongs to: |
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inositol 3,4-bisphosphate 4-phosphatase family |
Inositol polyphosphate-4-phosphatase type I A
Mass (kDA):
109.956 kDA
Human | |
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Location: | 2q11.2 |
Sequence: | 2; NC_000002.12 (98444538..98594392) |
Isoform 1 is expressed in the platelets, MEG- 01 megakaryocytes and Jurkat T-cells. Isoform 2 is expressed in the brain.
Early endosome membrane. Recycling endosome membrane. Cell membrane. Nucleus. Cytoplasm. Cell junction, synapse, postsynaptic density. Translocates to the plasma membrane upon EGF stimulation (PubMed:15716355). Shuttles between the cytoplasm and the nucleus, depending on the cell cycle stage, with highest amounts detected in the nucleus during the G0/G1phase (PubMed:30071275).
PMID: 7608176 by Norris F.A., et al. The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase.
PMID: 9295334 by Norris F.A., et al. The cDNA cloning and characterization of inositol polyphosphate 4- phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family.