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- Table of Contents
1 Citations 6 Q&As
Facts about Integrin-linked protein kinase.
Focal adhesion protein part of the complex ILK-PINCH. This complex is thought of as one of the convergence points of integrin- and growth factor-signaling pathway.
Human | |
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Gene Name: | ILK |
Uniprot: | Q13418 |
Entrez: | 3611 |
Belongs to: |
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protein kinase superfamily |
59 kDa serine/threonine-protein kinase; DKFZp686F1765; EC 2.7.11.1; ESTM24; ILK; ILK1; ILK-1; ILK2; ILK-2; integrin-linked kinase; integrin-linked kinase-2; integrin-linked protein kinase; p59; p59ILK
Mass (kDA):
51.419 kDA
Human | |
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Location: | 11p15.4 |
Sequence: | 11; NC_000011.10 (6603708..6610874) |
Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere.
PMID: 8538749 by Hannigan G.E., et al. Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase.
PMID: 10871859 by Janji B., et al. Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation.
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