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ILF3 Antibodies
AND ILF3 ELISA kits, ILF3 Proteins
Many biological assays use antibodies to detect ILF3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ILF3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ILF3 antibodies...
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ILF3 Infographic by Boster Bio
All ILF3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M02313-1
100 μl/vial
Cat # M02313-1
100 μl/vial
ILF3 Overview
Facts about Interleukin enhancer-binding factor 3.
Interleukin enhancer-binding factor 3 (ILF3)
RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) that are generated by back- splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory components living in the flanking introns of the circularized exons.
Plays thereby a function in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a broad assortment of transcriptional and post-transcriptional processes.
Gene Information
| Human | |
|---|---|
| Gene Name: | ILF3 |
| Uniprot: | Q12906 |
| Entrez: | 3609 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Double-stranded RNA-binding protein 76; double-stranded RNA-binding protein, 76 kD; DRBF; DRBP76M-phase phosphoprotein 4; dsRNA binding protein NFAR-2/MPP4; interleukin enhancer binding factor 3, 90kDa; interleukin enhancer-binding factor 3; MPHOSPH4interleukin enhancer binding factor 3, 90kD; MPP4MMP4; NF90CBTF; NFAR-1; NFAR2; NFARNF110; NF-AT-90; Nuclear factor associated with dsRNA; Nuclear factor of activated T-cells 90 kDa; nuclear factor of activated T-cells, 90 kD; TCP110; TCP80; Translational control protein 80
Molecular Weight
Mass (kDA):
95.338 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.2 |
| Sequence: | 19; NC_000019.10 (10654261..10692419) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Nucleus, nucleolus. Cytoplasm. Nucleus. Localizes in the cytoplasm in response to viral infection. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Diseases
- Malignant Neoplasms
- Neoplasms
- Infarction
- Myocardial Infarction
- Malignant Neoplasm Of Breast
- Neoplasms, Glandular And Epithelial
- Chronic Kidney Disease
- Mammary Neoplasms
- Epithelial Ovarian Cancer
- Ovarian Neoplasm
- Hepatitis
- Hepatitis C
Interacting Proteins
- PRMT1
Pathways
- Translation
- Localization
- Nuclear Export
- Cell Activation
- T Cell Activation
- Transport
- Regulation Of Gene Expression
- Mrna Stabilization
- Methylation
- Cell Cycle
- Mrna Processing
- Cell Growth
- Rna Processing
PTMs
- Phosphorylation
- Methylation
- Biotinylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ILF3
bosterbio.com/bosterbio-gene-info-cards/ILF3
References
PMID: 7519613 by Kao P.N., et al. Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90.
PMID: 10400669 by Patel R.C., et al. DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR.