This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
Interleukin-37 Antibodies
AND IL37 ELISA kits, Interleukin-37 Proteins
Many biological assays use antibodies to detect Interleukin-37, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Interleukin-37 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Interleukin-37 antibodies...
Previous: SEPTIN9
Next: SIGLEC9
IL37 Infographic by Boster Bio
All IL37 Products
Product
Figures
Specificity
Applications
Price
Human IL-37/IL-1F7 ELISA Kit PicoKine®
4 Citations 14 Q&As
Human
ELISA
$450
Cat # EK1363
96 wells/kit, with removable strips.
Cat # EK1363
96 wells/kit, with removable strips.
Human
Cell Culture
$77
Cat # PROTQ9NZH6-1
5ug,20ug,100ug
Cat # PROTQ9NZH6-1
5ug,20ug,100ug
IL37 Overview
Facts about Interleukin-37.
Interleukin-37 (IL37)
Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3.
Suppresses, or reduces, proinflammatory cytokine production, such as IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.
Gene Information
| Human | |
|---|---|
| Gene Name: | IL37 |
| Uniprot: | Q9NZH6 |
| Entrez: | 27178 |
Family
| Belongs to: |
|---|
| IL-1 family |
Alternative Names
FIL1 zeta; FIL1; FIL1(ZETA); FIL1ZFIL1 zeta; IL-1F7; IL-1F7IL-1 zeta; IL1H4IL1F7 (canonical product IL-1F7b); IL-1H4IL-1F7b (IL-1H4, IL-1H, IL-1RP1); IL-1RP1IL-1X protein; IL1RP1interleukin 1 family member 7; IL-1X; IL37; IL-37; interleukin 1 family, member 7 (zeta); interleukin 1, zeta; interleukin-1 family member 7; Interleukin-1 homolog 4; interleukin-1 superfamily z; Interleukin-1 zeta; Interleukin-1-related protein
Molecular Weight
Mass (kDA):
24.126 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q14.1 |
| Sequence: | 2; NC_000002.12 (112908885..112918882) |
Tissue Specificity
In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart.
Subcellular Localizations
Cytoplasm, cytosol. Nucleus. Secreted. Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions (PubMed:20935647). Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation (PubMed:18390730).
Diseases
- Inflammation
- Ankylosing Spondylitis
- Colitis
- Spondylitis
- Acute Hepatitis
- Systemic Infection
- Obesity
- Obesity, Morbid
Pathways
- Cell Activation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL37
bosterbio.com/bosterbio-gene-info-cards/IL37
References
PMID: 10744718 by Kumar S., et al. Identification and initial characterization of four novel members of the interleukin-1 family.
PMID: 11145836 by Pan G., et al. IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL- 1Rrp.
4 Publications of Boster Interleukin-37 Antibodies & ELISA Kits
- PubMed ID: 10.3389/fimmu.2018.02351, Profiling of B-Cell Factors and Their Decoy Receptors in Rheumatoid Arthritis: A...
- PubMed ID: 10.3389/fimmu.2018.01240, Profiling of Canonical and Non-Traditional Cytokine Levels in Interferon-β-Trea...
- PubMed ID: 29915590, Profiling of Canonical and Non-Traditional Cytokine Levels in Interferon-?-Treat...
- PubMed ID: 25880347, Yu J, Lu Y, Li Y, Xiao L, Xing Y, Li Y, Wu L. J Pharm Pharmacol. 2015 Sep;67(9):...
*More publications can be found for each product on its corresponding product page