Interleukin-36 gamma (IL36G)

Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that's thought to be present in epithelial barriers and to get involved in local inflammatory response; similar to the IL-1 system by which it shares the coreceptor IL1RAP.

Appears to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to induce tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS.