Interleukin-36 beta Antibodies

AND IL36B ELISA kits, Interleukin-36 beta Proteins

Many biological assays use antibodies to detect Interleukin-36 beta, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Interleukin-36 beta in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Interleukin-36 beta antibodies...

We validate the specificity of these antibodies to Interleukin-36 beta by testing them on tissues known to express IL36B positively and negatively. Browse below to find the IL36B antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: SEPTIN9 Next: SIGLEC9

IL36B Infographic by Boster Bio

All IL36B Products

Product

Figures

Specificity

Applications

Price

Anti-IL-1F8 IL36B Antibody

5 Q&As

Human

IHC, WB

$399
Cat # A08643
100μl

IL36B Interleukin-36 Beta Mouse Recombinant Protein

Mouse

$250
Cat # PROTQ9D6Z6
2ug, 10ug, 1mg

IL36 beta (IL36B) (NM_173178) Human Recombinant Protein

$1249
Cat # PROTQ9NZH7
20 µg

IL36 beta (IL36B) (NM_173178) Human Over-expression Lysate

Human

$628
Cat # LS027177
100 µg

IL36B Overview

Facts about Interleukin-36 beta.

IL36B 3D structure. Source: alphafold

Interleukin-36 beta (IL36B)

Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells connected to a pro-inflammatory reaction. Part of the IL-36 signaling system that is considered to be present in epithelial barriers and to get involved in local inflammatory reaction; similar to the IL-1 system with which it shares the coreceptor IL1RAP.

Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases.

Gene Information

Human
Gene Name:	IL36B
Uniprot:	Q9NZH7
Entrez:	27177

Family

Belongs to:

IL-1 family

Alternative Names

family of interleukin 1-eta; FIL1 eta; FIL1; FIL1-(ETA); FIL1H; FILI-(ETA); IL-1 eta; IL1-ETA; IL1F8 (Canonical product IL-1F8a); IL-1F8 (FIL1-eta); IL1F8; IL-1F8; IL1H2; IL-1H2; IL36 beta; IL-36 beta; IL36B; interleukin 1 family, member 8 (eta); interleukin 1, eta; Interleukin 36, Beta; Interleukin-1 eta; interleukin-1 family member 8; Interleukin-1 homolog 2; Interleukin-1 Superfamily e; Interleukin-36 Beta

Molecular Weight

Mass (kDA):
18.522 kDA

Genomic Context


Human

Location:	2q14.1
Sequence:	2; NC_000002.12 (113022089..113052867, complement)

Tissue Specificity

Expression at low levels in tonsil, bone marrow, heart, placenta, lung, testis and colon but not in any hematopoietic cell lines. Not detected in adipose tissue. Expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin. Increased levels are not detected in inflamed joint tissue.

Subcellular Localizations

Secreted.

Diseases

Psoriasis
Virus Diseases
Dermatitis
Periodontitis
Innate Immune Response
Periodontal Diseases
Dental Plaque
Inflammation

Periodontitis, Juvenile
Dysequilibrium Syndrome
Dermatologic Disorders

Pathways

Secretion
Cell Death
Immune Response
Protein Secretion
Pyroptosis
Pathogenesis

Lymphocyte Proliferation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL36B

References

PMID: 10744718 by Kumar S., et al. Identification and initial characterization of four novel members of the interleukin-1 family.

PMID: 10625660 by Smith D.E., et al. Four new members expand the IL-1 superfamily.