This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
Interleukin-36 beta Antibodies
AND IL36B ELISA kits, Interleukin-36 beta Proteins
Many biological assays use antibodies to detect Interleukin-36 beta, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Interleukin-36 beta in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Interleukin-36 beta antibodies...
Previous: SEPTIN9
Next: SIGLEC9
IL36B Infographic by Boster Bio
All IL36B Products
Product
Figures
Specificity
Applications
Price
Human
Cell Culture
$77
Cat # PROTQ9NZH7-3
5ug,20ug,100ug
Cat # PROTQ9NZH7-3
5ug,20ug,100ug
IL36B Overview
Facts about Interleukin-36 beta.
Interleukin-36 beta (IL36B)
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells connected to a pro-inflammatory reaction. Part of the IL-36 signaling system that is considered to be present in epithelial barriers and to get involved in local inflammatory reaction; similar to the IL-1 system with which it shares the coreceptor IL1RAP.
Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases.
Gene Information
| Human | |
|---|---|
| Gene Name: | IL36B |
| Uniprot: | Q9NZH7 |
| Entrez: | 27177 |
Family
| Belongs to: |
|---|
| IL-1 family |
Alternative Names
family of interleukin 1-eta; FIL1 eta; FIL1; FIL1-(ETA); FIL1H; FILI-(ETA); IL-1 eta; IL1-ETA; IL1F8 (Canonical product IL-1F8a); IL-1F8 (FIL1-eta); IL1F8; IL-1F8; IL1H2; IL-1H2; IL36 beta; IL-36 beta; IL36B; interleukin 1 family, member 8 (eta); interleukin 1, eta; Interleukin 36, Beta; Interleukin-1 eta; interleukin-1 family member 8; Interleukin-1 homolog 2; Interleukin-1 Superfamily e; Interleukin-36 Beta
Molecular Weight
Mass (kDA):
18.522 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q14.1 |
| Sequence: | 2; NC_000002.12 (113022089..113052867, complement) |
Tissue Specificity
Expression at low levels in tonsil, bone marrow, heart, placenta, lung, testis and colon but not in any hematopoietic cell lines. Not detected in adipose tissue. Expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin. Increased levels are not detected in inflamed joint tissue.
Subcellular Localizations
Secreted.
Diseases
- Psoriasis
- Virus Diseases
- Dermatitis
- Periodontitis
- Innate Immune Response
- Periodontal Diseases
- Dental Plaque
- Inflammation
Pathways
- Secretion
- Cell Death
- Immune Response
- Protein Secretion
- Pyroptosis
- Pathogenesis
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL36B
bosterbio.com/bosterbio-gene-info-cards/IL36B
References
PMID: 10744718 by Kumar S., et al. Identification and initial characterization of four novel members of the interleukin-1 family.
PMID: 10625660 by Smith D.E., et al. Four new members expand the IL-1 superfamily.