Interleukin-34 (Il34)

Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby has a significant role in innate immunity and in inflammatory processes.

Plays an essential role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling through CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity).