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IL31RA Antibodies
AND IL31RA ELISA kits, IL31RA Proteins
Many biological assays use antibodies to detect IL31RA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IL31RA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IL31RA antibodies...
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IL31RA Overview
Facts about Interleukin-31 receptor subunit alpha.
Interleukin-31 receptor subunit alpha (IL31RA)
Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5 (PubMed:11877449, PubMed:14504285, PubMed:15627637, PubMed:15194700).
May function in skin resistance (PubMed:15184896).Mediates IL31-induced itch, probably in a fashion dependent on cation channels TRPA1 and TRPV1 (By similarity). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | IL31RA |
| Uniprot: | Q8NI17 |
| Entrez: | 133396 |
Family
| Belongs to: |
|---|
| type I cytokine receptor family |
Alternative Names
class I cytokine receptor; CRL3; CRL3Glmr; Cytokine receptor-like 3; GLMR; GLM-R; GLM-RMGC125346; GP130 like receptor; Gp130-like monocyte receptor; Gp130-like receptor; hGLM-R; IL-31 RA; IL-31 receptor subunit alpha; IL-31R subunit alpha; IL31RA; IL-31RA; IL-31RAGPLCRL; IL-31R-alpha; interleukin 31 receptor A; interleukin-31 receptor subunit alpha; PRO21384; soluble type I cytokine receptor CRL3; zcytoR17
Molecular Weight
Mass (kDA):
82.954 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q11.2 |
| Sequence: | 5; NC_000005.10 (55840334..55922854) |
Tissue Specificity
Expressed in CD14- and CD56-positive blood cells (PubMed:11877449). Expressed in macrophages (PubMed:16461143, PubMed:18439099). Expressed in keratinocytes (PubMed:21261663). Expressed in a subset of dorsal root ganglia neurons (at protein level) (PubMed:24373353). Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin (PubMed:15184896, PubMed:11877449, PubMed:14504285). Expressed in bronchial and alveolar epithelial cells and pulmonary fibroblasts (PubMed:18439099). Detected in all of the myelomonocytic lineage (PubMed:14504285). Isoform 6: Expressed at higher levels in lesional skin compared to healthy skin of atopic dermatitis patients (PubMed:24373353).
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, presynaptic cell membrane. Cell projection, axon.
Diseases
- Inflammation
- Dermatitis
- Pruritus
- Dermatitis, Atopic
- Dermatologic Disorders
- Amyloidosis, Familial
- Amyloidosis
- Cutaneous Amyloidosis
- Inflammatory Bowel Diseases
- Intestinal Diseases
- Psoriasis
- Eczema
- Allergy
Pathways
- Cell Proliferation
- Secretion
- Immune Response
- Hypersensitivity
- Cell Migration
- Chemokine Production
- Cytokine Secretion
- Oxidative Phosphorylation
- Tropism
- Vascular Endothelial Growth Factor Production
- Cytokine Production
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL31RA
bosterbio.com/bosterbio-gene-info-cards/IL31RA
References
PMID: 11877449 by Ghilardi N., et al. A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5.
PMID: 15184896 by Dillon S.R., et al. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice.