SH3BP5 Antibodies

AND SH3BP5 ELISA kits, SH3BP5 Proteins

Many biological assays use antibodies to detect SH3BP5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SH3BP5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SH3BP5 antibodies...

We validate the specificity of these antibodies to SH3BP5 by testing them on tissues known to express SH3BP5 positively and negatively. Browse below to find the SH3BP5 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SH3BP5 Infographic by Boster Bio

All SH3BP5 Products

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Product

Figures

Specificity

Applications

Price

SH3BP5 (NM_001018009) Human Recombinant Protein

$1062
Cat # PROTO60239
20 µg

SH3BP5 (NM_004844) Human Over-expression Lysate

Human

$628
Cat # LS009467
100 µg

SH3BP5 Overview

Facts about SH3 domain-binding protein 5.

SH3BP5 3D structure. Source: alphafold

SH3 domain-binding protein 5 (SH3BP5)

Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells.

May be involved in BCR-induced apoptotic cell death. .

Gene Information

Human
Gene Name:	SH3BP5
Uniprot:	O60239
Entrez:	9467

Family

Belongs to:

SH3BP5 family

Alternative Names

Sab; SABSH3BP-5; SH3 binding protein; SH3 domain-binding protein 5; SH3 domain-binding protein that preferentially associates with BTK; SH3-domain binding protein 5 (BTK-associated)

Molecular Weight

Mass (kDA):
50.425 kDA

Genomic Context


Human

Location:	3p25.1
Sequence:	3; NC_000003.12 (15254353..15341380, complement)

Tissue Specificity

Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate.

Subcellular Localizations

Cytoplasmic vesicle membrane; Peripheral membrane protein. Mitochondrion. Colocalizes with RAB11A on cytoplasmic vesicle membranes.

Diseases

Agammaglobulinemia
X-linked Agammaglobulinemia
Immunologic Deficiency Syndromes
Neoplasms
Neoplasm Metastasis
Malignant Neoplasm Of Breast
B-cell Lymphomas
X-linked Combined Immunodeficiency Diseases
Injury To Liver
Malignant Neoplasms

Diffuse Large B-cell Lymphoma
Lymphoma
Mammary Neoplasms
Hepatotoxicity

Interacting Proteins

BTK
DISC1

Pathways

Cell Death
Gene Silencing
Cell Cycle
Cell Development
Localization

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SH3BP5

References

PMID: 9571151 by Matsushita M., et al. Identification and characterization of a novel SH3-domain binding protein, Sab, which preferentially associates with Bruton's tyrosine kinase (Btk).

PMID: 10339589 by Yamadori T., et al. Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein.