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- Table of Contents
Facts about Interleukin-26.
Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1.
Human | |
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Gene Name: | IL26 |
Uniprot: | Q9NPH9 |
Entrez: | 55801 |
Belongs to: |
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IL-10 family |
AK155; AK155IL-26interleukin-26; IL26; IL-26; interleukin 26; Protein AK155
Mass (kDA):
19.843 kDA
Human | |
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Location: | 12q15 |
Sequence: | 12; NC_000012.12 (68201349..68225810, complement) |
Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in serum of patients with Crohn's disease (at protein level).
Secreted.
PMID: 10729163 by Knappe A., et al. Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri.
PMID: 15178681 by Hor S., et al. The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains.