IL22RA1 Antibodies

AND IL22RA1 ELISA kits, IL22RA1 Proteins

Many biological assays use antibodies to detect IL22RA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IL22RA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IL22RA1 antibodies...

We validate the specificity of these antibodies to IL22RA1 by testing them on tissues known to express IL22RA1 positively and negatively. Browse below to find the IL22RA1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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IL22RA1 Infographic by Boster Bio

All IL22RA1 Products

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Product

Figures

Specificity

Applications

Price

Anti-IL-22 Receptor IL22RA1 Antibody

Human, Rat

ELISA, WB

$449
Cat # A05705
0.1 mg

Anti-IL-22 Receptor IL22RA1 Antibody

Human, Rat

ELISA, IF, IHC-P, ICC, WB

$449
Cat # A05705-1
0.1 mg

Anti-I22R1 IL22RA1 Antibody

Human, Mouse

ELISA, WB

$380
Cat # A05705-2
100ul

IL22RA1 (NM_021258) Human Over-expression Lysate

Human

$628
Cat # LS058985
100 µg

IL22RA1 Overview

Facts about Interleukin-22 receptor subunit alpha-1.

IL22RA1 3D structure. Source: alphafold

Interleukin-22 receptor subunit alpha-1 (IL22RA1)

Part of the receptor for IL20, IL22 and IL24.
Part of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways.

IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Part of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation.

Gene Information

Human
Gene Name:	IL22RA1
Uniprot:	Q8N6P7
Entrez:	58985

Family

Belongs to:

type II cytokine receptor family

Alternative Names

CRF2-9; CRF2-9interleukin 22 receptor; Cytokine receptor class-II member 9; Cytokine receptor family 2 member 9; IL-22 R alpha 1; IL-22 receptor subunit alpha-1; IL22R alpha 1; IL22R; IL22R1; IL22RA1; IL-22Ra1; IL-22R-alpha-1; IL-TIF-R1; interleukin 22 receptor, alpha 1; interleukin-22 receptor subunit alpha-1; zcytoR11

Molecular Weight

Mass (kDA):
63.077 kDA

Genomic Context


Human

Location:	1p36.11
Sequence:	1; NC_000001.11 (24119771..24143179, complement)

Tissue Specificity

Expressed in colon, liver, lung, pancreas and kidney. No expression in immune cells such as monocytes, T-cells, and NK-cells. Expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions; Strongly expressed on central nervous system vessels within infiltrated multiple sclerosis lesions. Overexpressed in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients.

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

Chronic Sinusitis
Nasal Polyps
Rhinorrhea
Malignant Neoplasm Of Breast
Polyps
Atherosclerosis
Insulin Resistance
Malignant Neoplasms
Neoplasms
Obesity
Innate Immune Response

Sinusitis
Paratuberculosis
Inflammation
Mammary Neoplasms
Pigmentation Disorders
Diarrhea

Interacting Proteins

IL10RB
IL22

Pathways

Pathogenesis
Pigmentation

PTMs

Disulfide bond

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL22RA1

References

PMID: 10875937 by Xie M.-H., et al. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R.

PMID: 11035029 by Kotenko S.V., et al. Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL- TIF) receptor complexes.