Interleukin-20 Antibodies

Interleukin-20 (IL20)

Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative actions are antagonized by IL10.

May act through STAT3. .

Gene Information

Human
Gene Name:	IL20
Uniprot:	Q9NYY1
Entrez:	50604

Family

Belongs to:
IL-10 family

Alternative Names

Cytokine Zcyto10; IL10D; IL20; IL-20; IL-20ZCYTO10four alpha helix cytokine; interleukin 20; interleukin-20; MGC96907

Molecular Weight

Mass (kDA):
20.072 kDA

Genomic Context

Human
Location:	1q32.1
Sequence:	1; NC_000001.11 (206865247..206869223)

Tissue Specificity

Expressed in most tissues and five major cell types: epithelial cells (primarily skin, buccal mucosa, tongue, nasal mucosa, lung, ureter, breast, prostate, fallopian tube, and adrenal gland), myoepithelial cells (mainly prostate), endothelial cells (mainly in small vessels or capillaries), macrophages, and skeletal muscle. Isoform 2 was detected in the lung tissue only.

Subcellular Localizations

Secreted.

Diseases

• Dysequilibrium Syndrome
• Inflammatory Response
• Psoriasis
• Hepatitis
• Inflammation
• Hepatitis, Chronic
• Dermatitis, Atopic
• Hepatitis C, Chronic
• Hepatitis B
• Carcinoma
• Malignant Neoplasms
• Systemic Onset Juvenile Chronic Arthritis

• Asthma
• Airway Disease
• Bronchiolitis
• Pustulosis Of Palms And Soles
• Arthritis, Juvenile Rheumatoid
• Infective Disorder
• Respiratory Syncytial Virus Bronchiolitis

Pathways

• Pathogenesis
• Pigmentation
• Inflammatory Response
• Senescence
• Replicative Senescence
• Cytokine Production
• Cell Cycle
• Cellular Senescence

• Aging
• Keratinocyte Differentiation
• Cell Cycle Arrest

PTMs

• Disulfide bond

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL20

The Best Uses Of The IL20 Marker By Boster Bio

This article will explain the benefits of primary antibodies and boster bio products for IL20 markers. This article will give an overview of Boster Bio's products, as well as their applications. Moreover, you will learn about their pricing. You will be able determine which products are right to use for your research after reading this article. No matter if you need an IL20 mark for research or clinical trials, you will be able select the one that best suits you.

Boster offers high-affinity prim antibodies

Flow cytometry can be used to study biological processes and populations. It involves the passage a sample of blood through a cell culture medium in an attempt to identify proteins. Boster Bio's primary antibodies are monoclonal or polyclonal with high specificities. Boster Bio's antibodies are easily accessible and have been cited in many scientific publications.

The primary antibody used in research and diagnostics is derived from the immune system of a host. Its affinity and specificity determine its composition. High affinity antibodies bind to a specific antigen, while poor specificity means they bind to unintended antigens. Primary antibodies are useful tools to detect, measure, and purify the antigen of your interest.

Products

The IL-20 cytokine encodes a cytokine which is part of the R Alpha family of receptors. It is produced by monocytes, activated and keratinocytes. It shares sequences with IL-10, four other mammalian cytokines, and IL-20. In addition, IL-20 can be found in the human trachea. It is believed to act as a regulator of inflammation.

Numerous studies have shown that IL-20 is involved in the pathogenesis traumatic SCI. IL-20 also promotes proliferation of multipotent hematopoietic spermatogenitor cells. In addition, it directs differentiation and expansion of keratinocytes. IL-20 also promotes the expression of proinflammatory mediators in keratinocytes.

IL-20 has been linked to a variety of inflammatory diseases including psoriasis and contact hypersensitivity. It also has been associated with rheumatoidarthritis and atherosclerosis. It has also been linked with osteoarthritis. However, it has yet to be shown that this marker is associated with osteoarthritis-related radiographic and clinical symptoms. In this regard, it is important to note that this gene is related to other markers, including IL-18 and TNF-a.

Although more research is needed on IL-20, it has been suggested as a potential treatment for SCI. It regulates the reactivation, and axon growth. Therefore, it may be a promising therapeutic target. Further research is needed in order to understand its exact mechanisms. Polarization of adaptive immunity is believed to be the reason for IL-20's protective role. IL-20 can, for instance, promote axonal recovery.

The role of IL-20 in the SCI recovery process is unclear, but it is important in neuroinflammatory processes. It plays a crucial role in the activation and regenerative process axons. It also inhibits neuronal regrowth via Sema3A/NRP-1. Its effect is thought to be crucial in the early stages of SCI.

Applications

The IL20 mark is one of many proteins found at the surface of different tissues. This marker can distinguish between transfected and untransfected cells by its ability to recognize altered phenotypes within these tissues. The protein can also easily be humanized or modified to improve its therapeutic capabilities. Psoriasis is a condition that causes IL20 to be activated.

Several motifs within the IL-20 mRNA have been shown to be associated with instability. The IL-20 polypeptide is very similar to IL-10, four mammalian cytokines, as well as several viral products. These proteins have important roles in inflammation and hyperproliferation of keratinocytes, and it has been shown to play a role in various cellular processes. Endothelial cells also contain the IL-20 receptor.