IL18RAP Antibodies

Interleukin-18 receptor accessory protein (IL18RAP)

Within the IL18 receptor complex, doesn't mediate IL18- binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:9792649, PubMed:14528293, PubMed:25500532). May play a role in IL18- mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable).

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Gene Information

Human
Gene Name:	IL18RAP
Uniprot:	O95256
Entrez:	8807

Family

Belongs to:
interleukin-1 receptor family

Alternative Names

CD218a; IL-1 R5; IL-1 Rrp; IL-18 R alpha; IL-18 R1; IL18R alpha; IL18R1; IL-18Ra

Molecular Weight

Mass (kDA):
68.31 kDA

Genomic Context

Human
Location:	2q12.1
Sequence:	2; NC_000002.12 (102418550..102452568)

Tissue Specificity

Detected in adrenal gland, bone marrow, brain, fetal brain, fetal liver, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, prostate, salivary gland, skeletal muscle, spinal cord, testis, thymus, thyroid, trachea and uterus (PubMed:17897836). Strongly expressed in peripheral blood leukocytes and spleen and, to a lesser extent, in colon (PubMed:9792649). Specifically coexpressed with IL18R1 in T-helper 1 (Th1)cells (PubMed:10925275, PubMed:11046021, PubMed:10653850).

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.

Diseases

• Inflammation
• Neoplasms
• Rheumatoid Arthritis
• Autoimmune Reaction
• Arthritis
• Asthma
• Autoimmune Diseases
• Infective Disorder
• Malignant Neoplasms
• Degenerative Polyarthritis
• Innate Immune Response
• Autoimmunity
• Tissue Adhesions

• Crohn Disease
• Graft-vs-host Disease
• Hepatitis
• Inflammatory Bowel Diseases
• Carcinoma
• Psoriasis
• Communicable Diseases

Pathways

• Immune Response
• Pathogenesis
• Secretion
• Cytokine Production
• Cell Proliferation
• Cell Activation
• Interferon-gamma Production
• Innate Immune Response
• Cell Development
• T Cell Activation
• Cell Differentiation
• Histone Acetylation
• Inflammatory Response

• Chemokine Production
• Cell Maturation
• Glycosylation
• Hypersensitivity
• Adaptive Immune Response
• Reverse Transcription
• Methylation

PTMs

• Phosphorylation
• Cleavage

• Acetylation
• Methylation

• Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL18RAP

Boster Bio - Best Uses Of The IL18RAP Marker

You might be curious to know more about the anti-IL-18R beta/IL18RAP indicator and how it works. Before you make your decision, it is important to learn about Steven Boster's history. This article will examine his scientific career and his responsibilities as well as his history as scientist. Read on to find out more about Steven Boster as well as how the IL18RAP markers work.

Anti-IL-18R Beta/IL-18RAP Marker

Boster Bio uses the Anti-IL-18R Beta/IL-18RAP marker to detect human mRNA expressing a particular receptor of cytokines called tNF. The receptor is found in many tissues including the lung, spleen and leukocytes. The antibody is used in a variety of therapeutic applications, including immunoassays.

The tetrameric structure of antibodies is a feature that distinguishes them from other proteins. The basic structure of antibodies is a variable region, three regions that are hypervariable, and three regions that are complementarity determining (CDRs). These CDRs recognise the antigen and help it to bind. The framework areas align the CDRs for two chains in a couple, allowing antibodies the ability to bind with a specific epitope. Each heavy and light chain is composed of a number of domains. The amino acids are assigned according to the Kabat sequences of proteins of immunological interest.

IL-18 receptor binding is accomplished by several antigen binding proteins. CDRL1 (SEQ ID Nos.69 and 71) are two examples that bind to a specific aIL-18 receptor. The antibody then binds to the antigen in a second step. The antibody is then released by the body in response.

The Boster Bio Anti-IL-18R Beta/IL-18RAP Marker reacts to Human. The Anti-IL-18R Beta/IL-18RAP Marker in Boster Bio is part of their Picoband(tm) catalog and can be stored at -20degC or frozen at -80degC. The product contains Trehalose and Na2HPO4 to stabilize its antigen-binding activity.

The Anti-IL-18RAP/IL-18RAP Marker in BoSTER Bio was designed to detect psoriasis. These proteins are involved with inflammation. The body may produce different results if it has too many of these molecules. Chronic inflammation is a common symptom of conditions like psoriatic arteriosis and psoriatic arthropathy.

Inflammation can be associated with many human diseases. Therefore, inflammatory biomarkers are very valuable in diagnosing and prognosing disease. They can be used to identify drug targets and provide new insights into the disease's pathogenesis. It is important for us to know which proteins could be used as biomarkers in the diagnosis of disease.

There are many subclasses in the IgG family. IgG1 & IgG2 are the most popular. The latter two are heterologous. This means they can be used in conjunction with each other. For example, the anti-IL-18RAP Marker in Boster Bio has five subclasses, including CDRL1, CDRL2, and CDRL2.

History of Steven Boster

You can learn about the life of Steve Boster in several ways. Public records are available online for anyone who is interested in the past of the person or simply want to know more about the family history. These records include the person's current and past addresses, phone numbers, and emails. You can also find out if Steve Boster has any relatives. You can search for him by state to see which records are available.

Steve Boster was born in Joliet, IL. He was the only child of Evelyn and James Meier Boster. He was a long-standing retail sales manager. He was also an active member of Concordia Hall of Staunton. Survivors include his two daughters, Crystal Boster and Natosha Peck. Boster was also survived and cared for by his 4 Brothers, Jack Boster & Sandra Blanton. His sisters Kimberly and Tammy, as well as his nephew Jonathan and nieces and nephews, are his survivors.

His responsibilities, as a scientist

Dr. Boster Siwila recently presented a blueprint for a Nuclear Policy for Zambia 2020. This blueprint provides a framework for peaceful nuclear science in Zambia and supports a diversified economy for sustainable development. It is part of Vision 2030, the country's long-term developmental plan. Implementation of policy provisions will be overseen by various ministries. Boster must now deal with a scandal surrounding sexual misconduct.