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- Table of Contents
1 Citations 6 Q&As
Facts about Interleukin-15 receptor subunit alpha.
Expression of distinct isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 don't bind IL15.
Human | |
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Gene Name: | IL15RA |
Uniprot: | Q13261 |
Entrez: | 3601 |
Belongs to: |
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No superfamily |
CD215 antigen; CD215; IL15 R alpha; IL-15 R alpha; IL-15 receptor subunit alpha; IL-15R alpha; IL15RA; IL-15Ra; IL-15R-alpha; interleukin 15 receptor, alpha; interleukin-15 receptor subunit alpha; MGC104179
Mass (kDA):
28.233 kDA
Human | |
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Location: | 10p15.1 |
Sequence: | 10; NC_000010.11 (5948897..5978741, complement) |
Isoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 are widely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.
Membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Cell surface. Mainly found associated with the nuclear membrane.; [Isoform 5]: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.; [Isoform 6]: End
PMID: 8530383 by Anderson D.M., et al. Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes.
PMID: 9110174 by Yu W., et al. Large-scale concatenation cDNA sequencing.
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